Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The impact of pretreatment with bolus dose of enteral glutamine on acute lung injury induced by oleic acid in rats
Journal of Anesthesia · Ocak 2014
YÖKSİS Kayıtları
The impact of pretreatment with bolus dose of enteral glutamine on acute lung injury induced by oleic acid in rats
Journal of Anesthesia · 2013 SCI-Expanded
PROFESÖR İBRAHİM ÖZKAN ÖNAL →
The impact of pretreatment with bolus dose of enteral glutamine on acute lung injury induced by oleic acid in rats
Journal of Anesthesia · 2014 SCI-Expanded
PROFESÖR İBRAHİM ÖZKAN ÖNAL →
Makale Bilgileri
DergiJournal of Anesthesia
Yayın TarihiOcak 2014
Cilt / Sayfa28 · 354-362
Scopus ID2-s2.0-84903581740
Erişim🔓 Açık Erişim
Özet
Purpose: Both parenteral and enteral glutamine have shown beneficial effects in sepsis and ischemia/reperfusion-induced acute lung injury (ALI). Oleic acid (OA) has been used to induce ALI in experimental studies. In this study, we investigated the effects of pretreatment of a bolus dose of enteral glutamine on ALI induced by OA in rats. Methods: Twenty-eight adult female Sprague-Dawley rats weighing 240-300 g were divided into four groups, 7 in each. Group I and group II received normal saline for 30 days, group III and group IV received glutamine at a dose of 1 g/kg for 10 days by gavage, and in group II and group IV 100 mg/kg OA was administered i.v. Histopathological examination of the lung was performed with light and electron microscopy. Levels of protein carbonyl, malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase levels were measured in tissue samples. Levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, and total tissue oxidant status and total tissue antioxidant status were measured in serum samples. Results: Light microscopy showed that the total lung injury score of group IV was significantly lower than group II. Change in thickness of the fused basal lamina was not significantly different in groups II and IV under electron microscopy. TNF-α, IL-6, and IL-10 serum levels were higher in group II when compared to group I and significantly attenuated in group IV. Conclusion: Pretreatment with a bolus dose of enteral glutamine minimized the extent of ALI induced by OA in rats. © 2013 Japanese Society of Anesthesiologists.
Yazarlar (10)
1
A. Ebru Salman
2
Fahri Yetisir
3
Mehmet Kilic
4
Ozkan Onal
ORCID: 0000-0002-5574-1901
5
Ahmet Dostbil
6
N. Dilara Zeybek
7
Mustafa Aksoy
8
Figen Kaymak
9
Tuǧrul Çelik
10
Süheyla Ünver
Anahtar Kelimeler
Glutamine
Lung injury
Oleic acid
Pneumocyte
Kurumlar
Anka-Lab. Biochemistry
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Ataturk Training and Research Hospital
Izmir Turkey
Etlik Training and Research Hospital
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Metrikler
10
Atıf
10
Yazar
4
Anahtar Kelime