Scopus
YÖKSİS Eşleşti
Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial
Regional Anesthesia and Pain Medicine · Ağustos 2024
YÖKSİS Kayıtları
Nitrous oxide for the treatment of complex regional pain syndrome: a randomized blinded trial
Regional Anesthesia & Pain Medicine · 2024 SCI
PROFESÖR İBRAHİM ÖZKAN ÖNAL →
Makale Bilgileri
DergiRegional Anesthesia and Pain Medicine
Yayın TarihiAğustos 2024
Cilt / Sayfa49 · 573-580
Scopus ID2-s2.0-85175788428
Özet
Introduction Complex Regional Pain Syndrome (CRPS) is a debilitating neuropathic condition often refractory to conventional treatments. N-methyl-D-aspartate (NMDA) receptor antagonists have a well-established role in the development and modulation of chronic neuropathic pain. Nitrous oxide is widely used and generally safe anesthetic gas with NMDA receptor antagonist activity. We therefore tested the hypothesis that brief periods of nitrous oxide exposure reduce pain in patients with CRPS. Methods Patients with a diagnosis of CRPS were randomized to either 2 hours of nitrous oxide exposure on three alternating days (Nitrous Oxide) versus a placebo air/oxygen mixture (Air-Oxygen). Our primary outcome was patient-reported pain scores at 1 week and 1 month. Secondary and exploratory outcomes were physical and mental health (PRMOIS-29 v2 survey), specific neuropathic pain symptoms (McGill short-form questionnaire), and opioid consumption. Results 44 patients participated in the study; 20 were randomized to Nitrous Oxide and 24 were assigned to Air-Oxygen. Pain scores did not differ significantly, with the estimated difference in means (Nitrous Oxide−Air-Oxygen) of −0.57 (95% CI: −1.42 to 0.28) points, p=0.19. There were also no differences detected in secondary outcomes, with the estimated difference in mean Z-scores for physical health (Nitrous Oxide−Air-Oxygen) of 0.13 (95% CI: −0.16 to 0.43), mental health 0.087 (95% CI: −0.31 to 0.48), and Patient Global Impression of Change score −0.7 (95% CI: −1.85 to 0.46). Conclusions Compared with air/oxygen, 2 hours of nitrous oxide/oxygen exposure for three sessions did not provide meaningful therapeutic potential for patients with chronic CRPS. Our results do not support using nitrous oxide for the treatment of CRPS.
Yazarlar (14)
1
Jason Hale
2
Jijun Xu
ORCID: 0000-0002-5137-8199
3
Dong Wang
4
Fabio Rodriguez-Patarroyo
5
Omer Bakal
6
Orkun Kopac
ORCID: 0000-0002-2414-0951
7
Ece Yamak Altinpulluk
8
Ozkan Onal
ORCID: 0000-0002-5574-1901
9
Jack E. Brooker
10
Miguel Cruz
11
Marco Maurtua
12
Ruben Agudelo-Jimenez
13
Daniel I. Sessler
14
Alparslan Turan
Kurumlar
Cleveland Clinic Foundation
Cleveland United States
Selçuk Üniversitesi
Selçuklu Turkey
University of Pittsburgh School of Medicine
Pittsburgh United States
University of Washington
Seattle United States