Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Autologous transplantation of arterial cells improves cardiac function in a rabbit model of infarcted myocardium
Stem Cells and Development · Haziran 2010
YÖKSİS Kayıtları
Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium
Stem Cells and Development · 2010 SCI
Prof. Dr. NAZİF AYGÜL →
Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium
Stem Cells and Development · 2010 SCI-Expanded
Prof. Dr. AHMET AK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium
2010 ISSN: 1547-3287 SCI-Expanded
Prof. Dr. AHMET AK →
Autologous Transplantation of Arterial Cells Improves Cardiac Function in a Rabbit Model of Infarcted Myocardium
2010 ISSN: 1547-3287 SCI
Prof. Dr. NAZİF AYGÜL →
Makale Bilgileri
ISSN15473287
Yayın TarihiHaziran 2010
Cilt / Sayfa19 · 927-934
Scopus ID2-s2.0-77954190945
Özet
Cellular cardiomyoplasty is a promising approach for the treatment of severe heart failure. However, the question which cell line is the best to use is still a matter of debate. In this study, we aimed to evaluate the efficacy of arterial media-intima cell suspension (AMICS) transplantation in rabbit myocardial infarct model. The study was divided into 2 groups: group A (the cell-treated group, n = 9) and group B (the medium injection group, n=8). Group A was further divided into 2 subgroups as branch-1 (treated with unlabeled cells) and branch-2 (treated with iron-labeled cells). The experimental myocardial infarction (MI) was induced by ligation of left anterior descending coronary artery with a combination of cryoinjury. Ten days after the MI, cells obtained from autologous femoral arteries were injected into the injured myocardium of group A, while group B received an injection of only DMEM medium. Clinical, echocardiographic, and histopathologic evaluations were done. As compared to the ninth day values, echocardiography showed a significant improvement in systolic functions and left ventricular (LV) dimensions of the cell-treated group on the 30th day. In the heart biopsy sections of branch-1, the immunostained injected cells were observed to exist closely, suggesting an organization. Cells existing separately and lumen-like structure organizations stained positive with both smooth muscle cell (SMC) α-actin and Prussian Blue were also showed in the histological observation of branch-2. Autologous AMICS transplantation seems to be a feasible and efficacious method for cellular cardiomyoplasty in our rabbit model. © Copyright 2010, Mary Ann Liebert, Inc.
Yazarlar (8)
1
Mehmet Tokac
2
Murad Aktan
3
Ahmet Ak
4
Selcuk Duman
5
Lale Tokgozoglu
6
Nazif Aygül
7
Y. Paksoy
8
Yael Porat
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Sanz Medical Center-Laniado Hospital Israel
Netanya Israel
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Stem Cells and Development
Q3
SJR Skoru0,532
H-Index142
YayıncıMary Ann Liebert Inc.
ÜlkeUnited States
Developmental Biology (Q3)
Hematology (Q3)
Cell Biology (Q4)
Metrikler
2
Atıf
8
Yazar