Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Synthesis of new N,N′-bis[1-aryl-3-(piperidine-1-yl)propylidene] hydrazine dihydrochlorides and evaluation of their cytotoxicity against human hepatoma and breast cancer cells
Journal of Enzyme Inhibition and Medicinal Chemistry · Ocak 2014
YÖKSİS Kayıtları
Synthesis of New N N bis 1 aryl 3 piperidine 1 yl propylidene hydrazine Dihydrochlorides and Evaluation of Their Cytotoxicity against Human Hepatoma and Breast Cancer Cells
Journal of Enzyme Inhibiton and Medicinal Chemistry · 2013 SCI-Expanded 2 atıf
PROFESÖR KAAN KÜÇÜKOĞLU →
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiOcak 2014
Cilt / Sayfa29 · 420-426
Scopus ID2-s2.0-84900812986
Erişim🔓 Açık Erişim
Özet
N,N0-Bis[1-aryl-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides were synthesized by the reaction of 2 mols of 1-aryl-3-(piperidine-1-yl)-1- propanone hydrochlorides with 1 mol of hydrazine hydrate. Aryl part was C 6H5 (P1), 4-CH3C6H4 (P2), 4-CH3OC6H4 (P3), 4-HOC6H 4 (P4), 4-ClC6H4 (P5), 3-CH3OC 6H4 (P6), 4-FC6H4 (P7) and 4-BrC6H4 (P8). Except P1, all compounds were reported for the first time. The chemical structures were confirmed by UV, 1H NMR, 13C NMR and HRMS spectra. P1, P2, P7 and P8 against human hepatoma (Huh7) cells and P1, P2, P4, P5, P6, P7 and P8 against breast cancer (T47D) cells have shown cytotoxicity. P1, P2 and P7 had more potent cytotoxicity against Huh7 cells than the reference compound 5-FU, whereas only P2 was more potent than the 5-FU against T47D cells. Representative compound P7 inhibited the mitochondrial respiration at 144, 264 and 424 mM concentrations dose-dependantly in liver homogenates. The results suggest that P1, P2, P7 and P8 may serve as model compounds for further synthetic studies. © 2014 Informa UK Ltd.
Yazarlar (8)
1
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
2
H. I. Gul
3
Rengul Cetin-Atalay
4
Yosra Baratli
5
Anne Laure Charles
6
Murat Süküroglu
7
Mustafa Gul
8
Bernard Geny
Anahtar Kelimeler
Cytotoxicity
Huh7
Hydrazone
Mannich bases
Mitochondrial respiration
T47D
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Bilkent Üniversitesi
Ankara Turkey
Gazi Üniversitesi
Ankara Turkey
Université de Strasbourg
Strasbourg France
Metrikler
15
Atıf
8
Yazar
6
Anahtar Kelime