Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
Journal of Enzyme Inhibition and Medicinal Chemistry · Ağustos 2015
YÖKSİS Kayıtları
Synthesis of 3 aroyl 4 aryl 1 isopropylamino 4 piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
Journal of Enzyme Inhibition and Medicinal Chemistry · 2014 SCI
Prof. Dr. KAAN KÜÇÜKOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of 3 aroyl 4 aryl 1 isopropylamino 4 piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
2014 ISSN: 1475-6366 SCI
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of 4 2 substituted hydrazinyl benzenesulfonamides and their carbonic anhydrase inhibitory effects
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Anthraquinone profile antioxidant and enzyme inhibitory effect of root extracts of eight i Asphodeline i taxa from Turkey can i Asphodeline i roots be considered as a new source of natural compounds title
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic
<i>Thymus spathulifolius</i>
Hausskn. et Velen
</title>
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Microwave-assisted synthesis and bioevaluation of new sulfonamides
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
2013 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
Makale Bilgileri
ISSN14756366
Yayın TarihiAğustos 2015
Cilt / Sayfa30 · 564-568
Scopus ID2-s2.0-84937201971
Özet
Some 4-piperidinol derivatives were synthesized and their cytotoxicity was tested against human hepatoma (Huh7) and breast cancer (T47D) cells. Aryl part was changed as phenyl in 2a, 4-methylphenyl in 2b, 4-methoxyphenyl in 2c, 4-chlorophenyl in 2d, 4-fluorophenyl in 2e, 4-bromophenyl in 2f, 4-nitrophenyl in 2g and 2-thienyl in 3. Compounds were synthesized and reported for the first time by this study except 2a and 2d. Chemical structures were confirmed by <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR, MS and elemental analyses. Compounds 2a (3.1 times), 2c (3.8 times), 2f (4.6 times), 2g (1.3 times) and 3 (3.2 times) had 1.3-4.6 times higher cytotoxic potency than the reference compound 5-FU against Huh7 cell line while all the compounds synthesized had shown lower activities against T47D cell line than 5-FU. In the light of these results, compounds 2a, 2c, 2f, 2g and 3 may serve as model compounds for further studies.
Yazarlar (4)
1
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
2
Ebru Mete
3
Rengul Cetin-Atalay
4
H. I. Gul
Anahtar Kelimeler
Cytotoxicity
Huh7 cells
isopropylamine
Mannich bases
T47D cells
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Bilkent Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Enzyme Inhibition and Medicinal Chemistry
Q2
OA
SJR Skoru0,857
H-Index98
YayıncıInforma Healthcare
ÜlkeUnited Kingdom
Drug Discovery (Q2)
Medicine (miscellaneous) (Q2)
Pharmacology (Q2)
Metrikler
5
Atıf
4
Yazar
5
Anahtar Kelime