Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects
Journal of Enzyme Inhibition and Medicinal Chemistry · Temmuz 2016
YÖKSİS Kayıtları
Synthesis of 4 2 substituted hydrazinyl benzenesulfonamides and their carbonic anhydrase inhibitory effects
Journal of Enzyme Inhibition and Medicinal Chemistry · 2016 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of 3 aroyl 4 aryl 1 isopropylamino 4 piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
2014 ISSN: 1475-6366 SCI
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of 4 2 substituted hydrazinyl benzenesulfonamides and their carbonic anhydrase inhibitory effects
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Anthraquinone profile antioxidant and enzyme inhibitory effect of root extracts of eight i Asphodeline i taxa from Turkey can i Asphodeline i roots be considered as a new source of natural compounds title
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic
<i>Thymus spathulifolius</i>
Hausskn. et Velen
</title>
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Microwave-assisted synthesis and bioevaluation of new sulfonamides
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
2013 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
Makale Bilgileri
ISSN14756366
Yayın TarihiTemmuz 2016
Cilt / Sayfa31 · 568-573
Scopus ID2-s2.0-84964621525
Erişim🔓 Açık Erişim
Özet
In this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by 1H NMR, 13CNMR, and HRMS. Ketones used were: Acetophenone (S1), 4-methylacetophenone (S2), 4-chloroacetophenone (S3), 4-fluoroacetophenone (S4), 4-bromoacetophenone (S5), 4-methoxyacetophenone (S6), 4-nitroacetophenone (S7), 2-acetylthiophene (S8), 2-acetylfuran (S9), 1-indanone (S10), 2-indanone (S11). The compounds S9, S10 and S11 were reported for the first time, while S1-S8 was synthesized by different method than literature reported using microwave irradiation method instead of conventional heating in this study. The inhibitory effects of 4-(2-substituted hydrazinyl)benzenesulfonamide derivatives (S1-S11) against hCA I and II were studied. Cytosolic hCA I and II isoenzymes were potently inhibited by new synthesized sulphonamide derivatives with Kis in the range of 1.79 ± 0.22-2.73 ± 0.08 nM against hCA I and in the range of 1.72 ± 0.58-11.64 ± 5.21 nM against hCA II, respectively.
Yazarlar (9)
1
H. I. Gul
2
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
3
Cem Yamali
ORCID: 0000-0002-4833-7900
4
Sinan Bilginer
5
Hafize Yuca
6
Iknur Ozturk
7
P. Taslimi
8
Gülçin
9
Claudiu T. Supuran
ORCID: 0000-0003-4262-0323
Anahtar Kelimeler
2-Acethylfuran
2-acethylthiophene
acetophenones
carbonic anhydrase
enzyme inhibition
indanone
sulfonamide
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
College of Sciences
Riyadh Saudi Arabia
Università degli Studi di Firenze
Florence Italy
Scimago Dergi (ISSN Eşleşmesi)
Journal of Enzyme Inhibition and Medicinal Chemistry
Q2
OA
SJR Skoru0,857
H-Index98
YayıncıInforma Healthcare
ÜlkeUnited Kingdom
Drug Discovery (Q2)
Medicine (miscellaneous) (Q2)
Pharmacology (Q2)
Metrikler
70
Atıf
9
Yazar
7
Anahtar Kelime