Scopus
YÖKSİS ISSN Eşleşti
SJR Q1
Synthesis and evaluation of new benzodioxole-based dithiocarbamate derivatives as potential anticancer agents and hCA-I and hCA-II inhibitors
European Journal of Medicinal Chemistry · Ocak 2017
YÖKSİS Kayıtları — ISSN Eşleşmesi
Novel 1 3 thiazolidin 4 one derivatives as promising anti Candida agents endowed with anti oxidant and chelating properties
2016 ISSN: 02235234 SCI
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Synthesis and Evaluation of New Benzodioxole Based Dithiocarbamate Derivatives as Potential Anticancer Agents and hCA I and hCA II Inhibitors
2017 ISSN: 0223-5234 SCI
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds
2009 ISSN: 02235234 SSCI
Prof. Dr. AHMET LEVENT BAŞ →
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents
2018 ISSN: 0223-5234 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Anti proliferative activity of aguerin B and a new rare nor guaianolide lactone isolated from the aerial parts of Centaurea deflexa
2011 ISSN: 0223-5234 SSCI 5 atıf
Prof. Dr. KUDDİSİ ERTUĞRUL →
Makale Bilgileri
ISSN02235234
Yayın TarihiOcak 2017
Cilt / Sayfa125 · 190-196
Scopus ID2-s2.0-84997112201
Özet
In the current work, new benzodioxole-based dithiocarbamate derivatives were synthesized via the reaction of N-(1,3-benzodioxol-5-ylmethyl)-2-chloroacetamide with appropriate sodium salts of N,N-disubstituted dithiocarbamic acids. These derivatives were evaluated for their cytotoxic effects on A549 human lung adenocarcinoma and C6 rat glioma cell lines. N-(1,3-Benzodioxol-5-ylmethyl)-2-[4-(4-nitrophenyl)-1-piperazinylthiocarbamoylthio]acetamide (10) can be identified as the most promising anticancer agent against C6 cell line due to its notable inhibitory effect on C6 cells with an IC50value of 23.33 ± 7.63 μg/mL when compared with cisplatin (IC50= 19.00 ± 5.29 μg/mL). On the other hand, compound 10 did not show any significant cytotoxic activity against A549 cell line. The compounds were also tested for their in vitro inhibitory effects on hCA-I and hCA-II. Generally, the tested compounds were more effective on CAs than acetazolamide, the reference agent. Among these compounds, N-(1,3-benzodioxol-5-ylmethyl)-2-[(morpholinyl)thiocarbamoylthio]acetamide (3) and N-(1,3-benzodioxol-5-ylmethyl)-2-[(thiomorpholinyl)thiocarbamoylthio]acetamide (4) were found to be the most effective compounds on hCA-I with IC50values of 0.346 nM and 0.288 nM, and hCA-II with IC50values of 0.287 nM and 0.338 nM, respectively.
Yazarlar (8)
1
Mehlika Dilek Altıntop
ORCID: 0000-0002-8159-663X
2
Belgin Sever
ORCID: 0000-0003-4847-9711
3
Gülşen Akalın Çiftçi
4
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
5
Ahmet Özdemir
6
Seyedeh Sara Soleimani
7
Hayrunnisa Nadaroglu
8
Zafer Asım Kaplancıklı
Anahtar Kelimeler
Benzodioxole
Cancer
Dithiocarbamate
Human carbonic anhydrase
Kurumlar
Anadolu Üniversitesi
Eskisehir Turkey
Atatürk Üniversitesi
Erzurum Turkey
Scimago Dergi (ISSN Eşleşmesi)
European Journal of Medicinal Chemistry
Q1
SJR Skoru1,142
H-Index215
YayıncıElsevier Masson s.r.l.
ÜlkeFrance
Drug Discovery (Q1)
Medicine (miscellaneous) (Q1)
Organic Chemistry (Q1)
Pharmacology (Q1)
Metrikler
36
Atıf
8
Yazar
4
Anahtar Kelime