Scopus
YÖKSİS Eşleşti
Some N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted)ureido/thioureido]benzenesulfonamides as carbonic anhydrase I and II inhibitors
Marmara Pharmaceutical Journal · Ocak 2017
YÖKSİS Kayıtları
Some N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted) ureido/thioureido]benzenesulfonamides as carbonic anhydrase I and II inhibitors
Marmara Pharmaceutical Journal · 2017 ESCI
PROFESÖR KAAN KÜÇÜKOĞLU →
Makale Bilgileri
DergiMarmara Pharmaceutical Journal
Yayın TarihiOcak 2017
Cilt / Sayfa21 · 89-95
Scopus ID2-s2.0-85006117448
Özet
In the present study, N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted)ureido]benzenesulfonamide (1-9) and N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted) thioureido]benzenesulfonamide (10-14) derivatives were synthesized from 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl) benzenesulfonamide (sulfamethizole). All new compounds were characterized by elemental analysis and various spectroscopic methods (FTIR,1H-NMR and MS). These new sulfonamide derivatives were investigated as inhibitors of carbonic anhydrase especially human carbonic anhydrase I and II. The new compounds showed higher activity against the human cytosolic CA I (IC50 values 0.144-15.65 nM) and CA II (IC50 values 0.109-17.95 nM) in comparison with the clinically used CA inhibitor acetazolamide.
Yazarlar (7)
1
Sevda Türk
2
Fatih Tok
3
Hülya Çelık
4
Sevgi Karakuş
5
Hayrunnisa Nadaroglu
6
Bedia Koçyığıt-Kaymakçioğlu
7
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
Anahtar Kelimeler
Carbonic anhydrase inhibitors
Sulfamethizole
Sulfonamide
Urea and thiourea
Kurumlar
Aǧrı İbrahim Çeçen Üniversitesi
Agri Turkey
Atatürk Üniversitesi
Erzurum Turkey
Marmara Üniversitesi
Istanbul Turkey
Metrikler
2
Atıf
7
Yazar
4
Anahtar Kelime