Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Microwave-assisted synthesis and bioevaluation of new sulfonamides
Journal of Enzyme Inhibition and Medicinal Chemistry · Ocak 2017
YÖKSİS Kayıtları
Microwave-assisted synthesis and bioevaluation of new sulfonamides
Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of 3 aroyl 4 aryl 1 isopropylamino 4 piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
2014 ISSN: 1475-6366 SCI
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of 4 2 substituted hydrazinyl benzenesulfonamides and their carbonic anhydrase inhibitory effects
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Anthraquinone profile antioxidant and enzyme inhibitory effect of root extracts of eight i Asphodeline i taxa from Turkey can i Asphodeline i roots be considered as a new source of natural compounds title
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic
<i>Thymus spathulifolius</i>
Hausskn. et Velen
</title>
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Microwave-assisted synthesis and bioevaluation of new sulfonamides
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
2013 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
Makale Bilgileri
ISSN14756366
Yayın TarihiOcak 2017
Cilt / Sayfa32 · 369-374
Scopus ID2-s2.0-85021308198
Erişim🔓 Açık Erişim
Özet
In this study, 4-[5-(4-hydroxyphenyl)-3-aryl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide derivatives (8-14) were synthesized for the first time by microwave irradiation and their chemical structures were confirmed by 1H NMR, 13C NMR and HRMS. Cytotoxic activities and inhibitory effects on carbonic anhydrase I and II isoenzymes of the compounds were investigated. The compounds 9 (PSE = 4.2), 12 (PSE = 4.1) and 13 (PSE = 3.9) with the highest potency selectivity expression (PSE) values in cytotoxicity experiments and the compounds 13 (Ki = 3.73 ± 0.91 nM toward hCA I) and 14 (Ki = 3.85 ± 0.57 nM toward hCA II) with the lowest Ki values in CA inhibition studies can be considered as leader compounds for further studies.
Yazarlar (8)
1
H. I. Gul
2
Cem Yamali
ORCID: 0000-0002-4833-7900
3
Fatma Yesilyurt
4
H. Sakagami
5
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
6
Gülçin
7
Mustafa Gul
8
Claudiu T. Supuran
ORCID: 0000-0003-4262-0323
Anahtar Kelimeler
Carbonic anhydrase
cytotoxicity
microwave
pyrazoline
sulfonamide
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
College of Sciences
Riyadh Saudi Arabia
Meikai University
Sakado Japan
Università degli Studi di Firenze
Florence Italy
Scimago Dergi (ISSN Eşleşmesi)
Journal of Enzyme Inhibition and Medicinal Chemistry
Q2
OA
SJR Skoru0,857
H-Index98
YayıncıInforma Healthcare
ÜlkeUnited Kingdom
Drug Discovery (Q2)
Medicine (miscellaneous) (Q2)
Pharmacology (Q2)
Metrikler
49
Atıf
8
Yazar
5
Anahtar Kelime