GC-MS Determination of Mexiletine After Derivatization with N-Methyl-N-(Trimethylsilyl) Trifluoroacetamide in Pharmaceutical Formulatios and Comparison with HPLC Method

Pharmaceutical Chemistry Journal · Eylül 2017

Makale Bilgileri

DergiPharmaceutical Chemistry Journal

Yayın TarihiEylül 2017

Cilt / Sayfa51 · 516-521

DOI10.1007/s11094-017-1646-8

Scopus ID2-s2.0-85030833274

Özet This paper describes two rapid, sensitive and specific methods based on GC-MS and HPLC techniques for determining mexiletine in pharmaceutical preparations. The GC-MS and HPLC calibration curves for mexiletine were linear in the concentration ranges of 0.5 – 5 and 0.75 – 10 μg/mL, respectively. The relative standard deviation (RSD) for intra- and inter-day precision was less than or equal to 2.18 and 5.84%, respectively. The developed methods were applied to a pharmaceutical preparation (mexitil) in capsulated forms, which do not require any preliminary separation or treatment of the samples. The results obtained by two methods were statistically compared, and no significant difference was found.