Scopus
YÖKSİS ISSN Eşleşti
SJR Q1
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
Bioorganic Chemistry · Mayıs 2019
YÖKSİS Kayıtları — ISSN Eşleşmesi
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix 4 arene bearing iminodicarboxylic phosphonic acid complexes modified iron oxide nanoparticles
2016 ISSN: 00452068 SCI-Expanded
Prof. Dr. ELİF ÖZYILMAZ →
Improvement of catalytic activity of Candida rugosa lipase in the presence of calix 4 arene bearing iminodicarboxylic phosphonic acid complexes modified iron oxide nanoparticles
2016 ISSN: 00452068 SCI
Prof. Dr. MUSTAFA YILMAZ →
Synthesis and evaluation of the antitumor activity of Calix [4] arene l-proline derivatives
2020 ISSN: 0045-2068 SCI
Prof. Dr. MUSTAFA YILMAZ →
Investigation of Inhibitory Properties of Some Hydrazone Compounds on hCA I, hCA II and AChE Enzymes
2019 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Antibacterial activities and DNA-cleavage properties of novel fluorescent imidazo-phenanthroline derivatives
2020 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. EMİNE ARSLAN →
Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors
2020 ISSN: 0045-2068 SCI-Expanded
Dr. Öğr. Üyesi MERVE GÖKŞİN KARAASLAN TUNÇ →
Synthesis and evaluation of the antitumor activity of Calix[4]arene l-proline derivatives
2020 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. MUSTAFA YILMAZ →
Synthesis and evaluation of the antitumor activity of Calix[4]arene l-proline derivatives
2020 ISSN: 0045-2068 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
New indole-7-aldehyde derivatives as melatonin analogues; synthesis and screening their antioxidant and anticancer potential
2020 ISSN: 0045-2068 SCI-Expanded
Doç. Dr. HANİF ŞİRİNZADE →
Discovery of 5-(or 6)-benzoxazoles and oxazolo[4,5-b]pyridines as novel candidate antitumor agents targeting hTopo IIα
2021 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi FATMA ZİLİFDAR FOTO →
Ortho-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials
2022 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi MUSTAFA KUL →
Biological activity and ADME/Tox prediction of some 2-substituted benzoxazole derivatives
2022 ISSN: 0045-2068 SCI Q1
Dr. Öğr. Üyesi FATMA ZİLİFDAR FOTO →
Ortho-hydroxy bioactive schiff base compounds: Design, comprehensive characterization, photophysical properties and elucidation of antimicrobial and mutagenic potentials
2022 ISSN: 0045-2068 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. AHMET UYSAL →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Preparation of water-soluble imidazole-functionalized pillar[5]arenes: The activities of antibacterial and antioxidant, catalytic reduction of 4-nitrophenol
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. MUSTAFA ÖZMEN →
Investigation of 2-substituted-5-methylsulfonylbenzoxazole derivatives as potential cholinesterase inhibitors: Synthesis, in vitro, and computational studies
2025 ISSN: 0045-2068 SCI-Expanded Q1
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Creative approaches for antibacterial, antioxidant and anticancer using honeycomb-type agents derived from a natural polymer
2025 ISSN: 0045-2068 SCI-Expanded Q1
Prof. Dr. AHMED NURİ KURŞUNLU →
Isatin-modified Calixarene derivatives: A comprehensive study on synthesis, enzyme inhibition, antioxidant, antimicrobial, and Antiproliferative activities
2025 ISSN: 0045-2068 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
Makale Bilgileri
Dergi
Bioorganic Chemistry
ISSN00452068
Yayın TarihiMayıs 2019
Cilt / Sayfa86 · 316-321
Scopus ID2-s2.0-85061197130
Özet
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, and Alzheimer's disease. Keeping this in mind, N,N′-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, N1-N11, P1, P4-P8, and R1-R6, were synthesized to investigate their inhibitory activity against hCA I, hCA II, and AChE enzymes. All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. According to the activity results, the most effective inhibitory compounds were in R-series with the K i values of 203 ± 55–473 ± 67 nM and 200 ± 34–419 ± 94 nM on hCA I, and hCA II, respectively. N,N′-Bis[1-(4-fluorophenyl)-3-(morpholine-4-yl)propylidene]hydrazine dihydrochlorides, N8, in N-series, N,N′-Bis[1-(4-hydroxyphenyl)-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides, P4, in P-series, and N,N′-bis[1-(4-chlorophenyl)-3-(pyrrolidine-1-yl)propylidene]hydrazine dihydrochlorides, R5, in R-series were the most powerful compounds against hCA I with the K i values of 438 ± 65 nM, 344 ± 64 nM, and 203 ± 55 nM, respectively. Similarly, N8, P4, and R5 efficiently inhibited hCA II isoenzyme with the K i values of 405 ± 60 nM, 327 ± 80 nM, and 200 ± 34 nM, respectively. On the other hand, P-series compounds had notable inhibitory effect against AChE than the reference compound tacrine and the K i values were between 66 ± 20 nM and 128 ± 36 nM. N,N′-Bis[1-(4-fluorophenyl)-3-(piperidine-1-yl)propylidene]hydrazine dihydrochlorides, P7, was the most potent compound on AChE with the K i value of 66 ± 20 nM. The other most promising compounds, N,N′-bis[1-(4-hydroxyphenyl)-3-(morpholine-4-yl)propylidene]hydrazine dihydrochlorides, N4 in N-series and N,N′-bis[1-(4-hydroxyphenyl)-3-(pyrrolidine-1-yl)propylidene]hydrazine dihydrochlorides, R4 in R-series were againts AChE with the K i values of 119 ± 20 nM, 88 ± 14 nM, respectively.
Yazarlar (5)
1
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
2
H. I. Gul
3
P. Taslimi
4
Gülçin
5
Claudiu T. Supuran
ORCID: 0000-0003-4262-0323
Anahtar Kelimeler
Acetylcholinesterase
Carbonic anhydrase
Enzyme inhibition
Hydrazone
Mannich base
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Firenze
Florence Italy
Son Atıflar
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Synthesis, spectroscopic characterizations, comparison of experimental, theoretical results, and molecular docking of novel hydrazone Schiff base compound N'-(4-hydroxy-3,5-dimethoxybenzylidene)-1-(2-methoxyphenyl)-5-methyl-1H-pyrazole-4-carbohydrazide
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· 2025 · DOI
Scimago Dergi (ISSN Eşleşmesi)
Bioorganic Chemistry
Q1
SJR Skoru0,786
H-Index95
YayıncıAcademic Press Inc.
ÜlkeUnited States
Organic Chemistry (Q1)
Biochemistry (Q2)
Drug Discovery (Q2)
Molecular Biology (Q3)
Metrikler
152
Atıf
5
Yazar
5
Anahtar Kelime