Scopus
Evaluation of Cytotoxic Properties of N,N'-bis[(1-aryl-3-heteroaryl)propylidene]-hydrazine dihydrochlorides
Pharmaceutical Chemistry Journal · Kasım 2020
Makale Bilgileri
DergiPharmaceutical Chemistry Journal
Yayın TarihiKasım 2020
Cilt / Sayfa54 · 784-787
Scopus ID2-s2.0-85096318367
Özet
N,N'-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, P1, P4 – P8, and R1 – R7, were assayed against human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4), human promyelocytic leukemia cell line (HL-60), and human normal oral cells (HGF, HPC, and HPLF) as non-tumor cells to evaluate their cytotoxic properties. Peplomycin was used as a reference compound. It was found that P- and R-series hydrazone compounds exhibited cytotoxicity in a range of 11 ± 0.68 – 300 ± 1.0 ± M. Compound P1 which is a non-substituted hydrazone containing piperidine ring and compound R2 which is a 4-methyl hydrazone derivative containing pyrrolidine ring showed the most potent cytotoxic activity. These hydrazone compounds may serve as promising candidates for further studies.
Yazarlar (3)
1
Kaan Kucukoglu
ORCID: 0000-0001-8977-9775
2
H. I. Gul
3
H. Sakagami
Anahtar Kelimeler
anticancer drugs
cancer
cytotoxic activity
hydrazone
Mannich base
selectivity
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Meikai University
Sakado Japan
Selçuk Üniversitesi
Selçuklu Turkey