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Interaction of donepezil with human serum albumin on amine-modified magnetic nanoparticles

Colloids and Surfaces A: Physicochemical and Engineering Aspects · Şubat 2014

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YÖKSİS Kayıtları
Interaction of donepezil with human serum albumin on amine modified magnetic nanoparticles
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS · 2014 SCI 4 atıf
PROFESÖR MUSTAFA ÖZMEN →
Interaction of donepezil with human serum albumin on amine modified magnetic nanoparticles
Colloids and Surfaces A: Physicochemical and Engineering Aspects · 2014 SCI-Expanded 1 atıf
PROFESÖR ESRA MALTAŞ ÇAĞIL →

Makale Bilgileri

DergiColloids and Surfaces A: Physicochemical and Engineering Aspects
Yayın TarihiŞubat 2014
Cilt / Sayfa442 · 139-145
DOI10.1016/j.colsurfa.2013.03.009
Scopus ID2-s2.0-84895059685
Özet The interaction between the drug donepezil and human serum albumin (HSA) was examined on the surface of amine modified superparamagnetic iron oxide nanoparticles (SPIONs), which were synthesized by the coprecipitation of ferrous and ferric salts with NH4OH and then modified with [3-Aminopropyl] triethoxysilane (APTES) to obtain functional amine groups on the nanoparticles' surface. Albumin's binding capacity to APTES-modified SPIONs was estimated by fluorescence spectroscopy. After HSA was bound to the APTES modified SPIONs, donepezil was interacted with the HSA-SPIONs. The binding capacity of the drug was determined using a calibration curve equation that was drawn using fluorescence spectroscopy at 325 and 387nm, the excitation and emission wavelengths. Thermodynamic parameters were estimated for the interaction of HSA and donepezil on amine-modified SPIONs. Binding was carried out spontaneously via electrostatic interaction. Binding was also examined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), scanning electron microscopy (SEM) and zeta-potential measurements. © 2013 Elsevier B.V.

Yazarlar (4)

1
Leman Buzoglu
2
Esra Maltas Cagil
3
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
4
Salih Yildiz

Anahtar Kelimeler

Donepezil Fluorescence spectroscopy Human serum albumin Magnetic nanoparticles

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey

Metrikler

30
Atıf
4
Yazar
4
Anahtar Kelime

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MUSTAFA ÖZMEN
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