Scopus
YÖKSİS Eşleşti
Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units
Medicinal Chemistry Research · Haziran 2020
YÖKSİS Kayıtları
Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units
Medicinal Chemistry Research · 2020 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
Synthesis and evaluation of anticancer effect of a novel molecule based-on pillar[5]arene including multi quinoline units
Medicinal Chemistry Research · 2020 SCI-Expanded
PROFESÖR AHMED NURİ KURŞUNLU →
Makale Bilgileri
DergiMedicinal Chemistry Research
Yayın TarihiHaziran 2020
Cilt / Sayfa29 · 1077-1083
Scopus ID2-s2.0-85084242684
Özet
In this study, pillar[5]arene containing ten terminal alkynyl-functional group was prepared and carried out an optimization procedure for target molecule with using 5-hydroxyquinoline molecule known with biological activity. The novel molecule was named as iso-QP[5] and characterized by FT-IR, melting point, NMR, elemental analysis, and mass spectroscopy. The aim was to evaluate the anticancer effects of iso-QP[5] on MCF7 human breast cancer cells. The IC50 dose of iso-QP[5] in MCF7 cells was found to be 25 µM for 24 h using XTT assay. Expressions of eight genes for apoptosis were determined by qPCR. The results showed a significant increase in the expression of BAX, CASP3, CASP9, CYCS, and P53 genes after treatment with iso-QP[5] in MCF7 cells. However, iso-QP[5] treatment significantly decreased expression of BCL2 and CASP8 genes. It is concluded that novel molecule iso-QP[5] caused apoptosis by regulating genes that are important in apoptosis in human breast cancer cells.
Yazarlar (5)
1
Canan Eroglu Gunes
2
Mehmet Ali Karaselek
3
Ahmed Nuri Kursunlu
4
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
5
Ercan Kurar
Anahtar Kelimeler
Apoptosis
Cytotoxicity
Pillar[5]arene
Quinoline
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
7
Atıf
5
Yazar
4
Anahtar Kelime