Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Synthesis of water soluble symmetric and asymmetric pillar[5]arene derivatives: Cytotoxicity, apoptosis and molecular docking studies
Journal of Molecular Structure · Ekim 2022
YÖKSİS Kayıtları
Synthesis of water soluble symmetric and asymmetric pillar[5]arene derivatives: Cytotoxicity, apoptosis and molecular docking studies
Journal of Molecular Structure · 2022 SCI-Expanded
Prof. Dr. MUSTAFA ÖZMEN →
Synthesis of water soluble symmetric and asymmetric pillar[5]arene derivatives: Cytotoxicity, apoptosis and molecular docking studies
Journal of Molecular Structure · 2022 SCI-Expanded
Prof. Dr. AHMED NURİ KURŞUNLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of new halo-substituted quinolinecarboxaldehyde-hydrazone derivatives, structural illuminations, investigation of effects on acetylcholinesterase activity and molecular modeling studies
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis, structural characterization, DFT calculations, molecular docking, and antimicrobial activity studies of some new oxazolo[4,5-b]pyridine derivatives
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis and spectral properties of pyrene based calix 4 arene
2013 ISSN: 0022-2860 SCI-Expanded
Prof. Dr. ÖZLEM ŞAHİN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI
Prof. Dr. BİLGE TANER →
Amine derivatized calix 4 arenes for sensitive extraction of cupric ion and formation of amine radical cation
2014 ISSN: 00222860 SCI
Prof. Dr. BEGÜM TABAKCI →
Determination of free radical on polycrystal of 4 4 bis chloroacetyl diphenylether An ESR study
2013 ISSN: 00222860 SCI
Prof. Dr. YUSUF CEYLAN →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 0022-2860 SCI
Prof. Dr. HATİCE TÜRK DAĞI →
An EPR study on radiation induced 4 hydroxyphenyl acetic acid polycrystalline
2015 ISSN: 00222860 SSCI
Prof. Dr. YUSUF CEYLAN →
Synthesis of novel chiral Schiff base and amino alcohol derivatives of calix 4 arene and chiral recognition properties
2012 ISSN: 00222860 SCI-Expanded 4 atıf
Prof. Dr. SERKAN ERDEMİR →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. SERKAN ERDEMİR →
A novel Schiff base bearing dopamine groups with tripodal structure Synthesis and its salen salophen bridged Fe Cr III capped complexes
2013 ISSN: 00222860 SCI-Expanded 1 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 13 atıf
Prof. Dr. AHMET OKUDAN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI 5 atıf
Prof. Dr. PERVİN SOYLU →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 00222860 SCI
Prof. Dr. PERVİN SOYLU →
Novel dipodal Schiff base compounds Synthesis characterization and spectroscopic studies
2015 ISSN: 00222860 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Nonlinear optical properties spectroscopic studies and structure of 2 hydroxy 3 methoxy N 2 chloro benzyl benzaldehyde imine
2004 ISSN: 00222860 SCI-Expanded 60 atıf
Prof. Dr. ASLI KARAKAŞ →
Nonlinear optical properties of some derivatives of salicylaldimine based ligands
2004 ISSN: 00222860 SCI-Expanded 65 atıf
Prof. Dr. ASLI KARAKAŞ →
The investigation of nonlinear optical properties of N 3 fluorophenyl naphthaldimine
2005 ISSN: 00222860 SCI-Expanded 22 atıf
Prof. Dr. ASLI KARAKAŞ →
Synthesis spectroscopic studies and nonlinear optical behavior of N N bis 2 hydroxy 1 naphthylmethylidene 1 methyl 1 2 diaminoethane N N O O nickel II
2006 ISSN: 00222860 SCI-Expanded 14 atıf
Prof. Dr. ASLI KARAKAŞ →
Makale Bilgileri
ISSN00222860
Yayın TarihiEkim 2022
Cilt / Sayfa1265
Scopus ID2-s2.0-85132735008
Özet
In this study, two water-soluble pillar[5]arenes, [1-(3-(trimethyl-azane)propoxy)-4-methoxyhydro-chloridepillar[5]arene (asym-P5) and 1,4-bis(2-(trimethyl-azane)ethoxy)hydrobromidepillar[5]arene (sym-P5), were synthesized and characterized using fourier transform infrared spectroscopy (FTIR), 1H and 13C nuclear magnetic resonance (1H-NMR and 13C-NMR). Cytotoxic and apoptotic effects of asym-P5 and sym-P5 on human hepatocellular carcinoma (HepG2), human breast adenocarcinoma (MDA-MB-231), human colon carcinoma (Caco-2), human prostate cancer (LnCap) and human embryonic kidney (HEK293) cell lines were determined by MTT, Annexin V-FITC apoptosis assays and quantitative analysis of mRNA levels of apoptosis related genes (Bax, Bcl-2, caspase 3, 8, and 9), respectively. asym-P5 not only reduced cell viability in all cell lines in a dose-dependent manner but also increased the apoptotic cell percentage significantly. sym-P5 was less effective than asym-P5 in inducing these effects in cancer cell lines. In RT-qPCR studies, it was observed that after asym-P5 treatment, Bax and caspase-3 mRNA levels increased, however, Bcl-2 levels decreased compared to the control group. As a result of the molecular docking, asym-P5 exhibited an energetically more favorable DNA binding affinity (-5.4 kcal/mol) than sym-P5 (-4.5 kcal/mol), where both ligands conformationally snug-fit into the major groove of DNA. These results demonstrated that asym-P5 had cytotoxic and apoptotic effects in cell lines.
Yazarlar (7)
1
Recep Liman
2
Ahmed Nuri Kursunlu
3
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
4
Sevki Arslan
5
Dogukan Mutlu
ORCID: 0000-0003-3259-5822
6
Erman Salih Istifli
7
Yaser Acikbas
ORCID: 0000-0003-3416-1083
Anahtar Kelimeler
Apoptosis
Molecular docking
mRNA
Pillar[5]arene
RT-PCR
Toxicity
Kurumlar
Çukurova Üniversitesi
Adana Turkey
Pamukkale Üniversitesi
Denizli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Usak University
Usak Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Molecular Structure
Q2
SJR Skoru0,628
H-Index134
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Inorganic Chemistry (Q2)
Organic Chemistry (Q2)
Spectroscopy (Q2)
Metrikler
8
Atıf
7
Yazar
6
Anahtar Kelime