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Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits

Veterinary Research Communications · Ocak 2006

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YÖKSİS Kayıtları
Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits
VETERINARY RESEARCH COMMUNICATIONS · 2006 SCI-Expanded 39 atıf
Prof. Dr. MUAMMER ELMAS →
Pharmacokinetics of Flunixin after Intravenous Administration in Healthy and Endotoxaemic Rabbits
Veterinary Research Communications · 2006 SCI-Expanded 28 atıf
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of Flunixin after Intravenous Administration in Healthy and Endotoxaemic Rabbits
Veterinary Research Communications · 2006 SCI-Expanded
Prof. Dr. ENVER YAZAR →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 6 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Pharmacokinetics of flunixin after intravenous administration in healthy and endotoxaemic rabbits
2006 ISSN: 0165-7380 SCI-Expanded 39 atıf
Prof. Dr. MUAMMER ELMAS →
The Evaluation of Coagulation Profiles in Calves with Suspected Septic Shock
2006 ISSN: 0165-7380 SSCI 23 atıf
Prof. Dr. RAMAZAN ÇÖL →
Pharmacokinetics of Flunixin after Intravenous Administration in Healthy and Endotoxaemic Rabbits
2006 ISSN: 0165-7380 SCI-Expanded
Prof. Dr. ENVER YAZAR →
Pharmacokinetics of Flunixin after Intravenous Administration in Healthy and Endotoxaemic Rabbits
2006 ISSN: 0165-7380 SCI-Expanded 28 atıf
Prof. Dr. KAMİL ÜNEY →
Wide bovine tick-borne pathogen spectrum: Predominancy of Theileria annulata and the first molecular detection of Ehrlichia minasensis in Turkey
2024 ISSN: 0165-7380 SCI-Expanded Q2
Arş. Gör. MUHAMMED HÜDAİ ÇULHA →
The Evaluation of Coagulation Profiles in Calves with Suspected Septic Shock
2006 ISSN: 0165-7380 SSCI 15 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →

Makale Bilgileri

Dergi Veterinary Research Communications
ISSN01657380
Yayın TarihiOcak 2006
Cilt / Sayfa30 · 73-81
DOI10.1007/s11259-005-3227-7
Scopus ID2-s2.0-31344467234
Özet The pharmacokinetics of flunixin were determined after intravenous bolus injection at a single dose (2.2 mg/kg) in healthy rabbits and diseased rabbits with Escherichia coli lipopolysaccharide-induced septic shock. Six adult New Zealand White rabbits were used. Concentrations of drug in plasma were determined by HPLC. Pharmacokinetics were best described by a two-compartment open model. In healthy rabbits, there was a high plasma clearance (0.62 L/(h kg)), and a relatively short elimination half-life (1.19 h). In endotoxaemic rabbits, total plasma clearance (0.43 L/(h kg)) was significantly lower (p<0.05), and elimination half-life (1.90 h) and AUC0-∞ (5.29 (μg h)/ml) were significantly higher (p<0.05) than in healthy animals. The changes of pharmacokinetics of flunixin in rabbits with septic shock could be of clinical significance, and may require monitoring of plasma flunixin levels in endotoxaemic status. © Springer Science + Business Media, Inc. 2006.

Yazarlar (4)

1
M. Elmas
2
E. Yazar
3
Kamil Üney
ORCID: 0000-0002-8674-4873
4
Ayse Karabacak

Anahtar Kelimeler

Endotoxaemia Flunixin Lipopolysaccharide Pharmacokinetics Rabbits

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Veterinary Research Communications
Q1
SJR Skoru0,524
H-Index69
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Veterinary (miscellaneous) (Q1)
Medicine (miscellaneous) (Q3)
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Metrikler

36
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

EY
ENVER YAZAR
Prof. Dr.

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