Scopus
YÖKSİS Eşleşti
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
Journal of Biomolecular Structure and Dynamics · Ocak 2024
YÖKSİS Kayıtları
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
Journal of Biomolecular Structure and Dynamics · 2025 SCI-Expanded
PROFESÖR AHMED NURİ KURŞUNLU →
Water-soluble Pillar[5]arene-based drug candidates for lung and breast cancer
Journal of Biomolecular Structure and Dynamics · 2025 SCI-Expanded
PROFESÖR MUSTAFA ÖZMEN →
Makale Bilgileri
DergiJournal of Biomolecular Structure and Dynamics
Yayın TarihiOcak 2024
Scopus ID2-s2.0-85189208904
Özet
The objective of research was to examine the likely anticancer effectiveness of distinct pillar[5] arene derivatives, ws-penta-P[5] and ws-deca-P[5], on breast and lung cancer cell lines in vitro. To achieve this goal, breast cancer (MCF7) cells, lung cancer (A549) cells, healthy cells (HEK293) were utilized. The IC50 dose of ws-penta-P[5] and ws-deca-P[5] was determined using the MTT method. Both treatment (pillar[5] arene applied) and control (pillar[5] arene not applied) groups were established for all three cell lines. Real-time polymerase chain reaction (qPCR) was used to evaluate changes in gene expression following pillar[5] arene treatment. Flow cytometry analysis was used to determine apoptosis and cell cycle arrest. The treatment group and control group results were compared after the study. The results revealed that in both cell lines treated with ws-deca-P[5], proapoptotic gene expressions were upregulated, while antiapoptotic gene expressions and caspase activation gene expressions were down-regulated. The flow cytometry apoptosis and cell cycle analysis in treatment group compared to the control, it was observed that the apoptosis rate increased in the ws-deca-P[5] and ws-deca-P[5] were shown to cause G0/G1 phase arrest in both cell groups. Results from our study that pillar[5] arene derivatives had the potential for treating breast and lung cancer, and more research is required in this area. Communicated by Ramaswamy H. Sarma.
Yazarlar (5)
1
Tugce Duran
ORCID: 0000-0002-7353-4527
2
Mehmet Ali Karaselek
3
Serkan Kuccukturk
4
Ahmed Nuri Kursunlu
5
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
Anahtar Kelimeler
apoptosis
breast cancer
Lung cancer
Pillar[5]arene
Kurumlar
Karamanoğlu Mehmetbey Üniversitesi
Karaman Turkey
Karatay Üniversitesi
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey