Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
Journal of Enzyme Inhibition and Medicinal Chemistry · Ocak 2020
YÖKSİS Kayıtları
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
Journal of Enzyme Inhibition and Medicinal Chemistry · 2020 SCI-Expanded
PROFESÖR MUSTAFA YILMAZ →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
Journal of Enzyme Inhibition and Medicinal Chemistry · 2020 SCI-Expanded
DOÇENT MEHMET OĞUZ →
Makale Bilgileri
DergiJournal of Enzyme Inhibition and Medicinal Chemistry
Yayın TarihiOcak 2020
Cilt / Sayfa35 · 1215-1223
Scopus ID2-s2.0-85084626416
Erişim🔓 Açık Erişim
Özet
A series of novel calix[4]azacrown substituted sulphonamide Schiff bases was synthesised by the reaction of calix[4]azacrown aldehydes with different substituted primary and secondary sulphonamides. The obtained novel compounds were investigated as inhibitors of six human (h) isoforms of carbonic anhydrases (CA, EC 4.2.1.1). Their antioxidant profile was assayed by various bioanalytical methods. The calix[4]azacrown substituted sulphonamide Schiff bases were also investigated as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase enzymes, associated with several diseases such as Alzheimer, Parkinson, and pigmentation disorders. The new sulphonamides showed low to moderate inhibition against hCAs, AChE, BChE, and tyrosinase enzymes. However, some of them possessed relevant antioxidant activity, comparable with standard antioxidants used in the study.
Yazarlar (8)
1
Mehmet Oguz
2
Erbay Kalay
3
Süleyman Akocak
ORCID: 0000-0003-4506-5265
4
Alessio Nocentini
ORCID: 0000-0003-3342-702X
5
Nebih Lolak
ORCID: 0000-0003-0578-2761
6
Mehmet Boga
7
Mustafa Yilmaz
8
Claudiu T. Supuran
ORCID: 0000-0003-4262-0323
Anahtar Kelimeler
antioxidant
Calix[4]azacrown
carbonic anhydrase
enzyme inhibition
Kurumlar
Adiyaman Üniversitesi
Adiyaman Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Firenze
Florence Italy
Metrikler
23
Atıf
8
Yazar
4
Anahtar Kelime