Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy
Journal of Veterinary Medical Science · Ocak 2017
YÖKSİS Kayıtları
Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy
Journal of Veterinary Medical Science · 2017 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy
J Vet Med Sci · 2017 SCI-Expanded
PROFESÖR ENVER YAZAR →
Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy
J Vet Med Sci · 2017 SCI-Expanded
PROFESÖR MUAMMER ELMAS →
Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy
Journal of Veterinary Medical Science · 2017 SCI
PROFESÖR AYŞE ER →
Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy
Journal of Veterinary Medical Science · 2017 SCI-Expanded
PROFESÖR BURAK DİK →
Makale Bilgileri
DergiJournal of Veterinary Medical Science
Yayın TarihiOcak 2017
Cilt / Sayfa79 · 1245-1252
Scopus ID2-s2.0-85025435287
Erişim🔓 Açık Erişim
Özet
The aim of this research was to compare plasma pharmacokinetics of ceftiofur sodium (CS) in healthy calves, and in calves with experimentally induced endotoxemia. Six calves received CS (2.2 mg/kg, IM) 2 hr after intravenous administration of 0.9% NaCl (Ceft group). After a washout period, the same 6 calves received CS 2 hr after intravenous injection of lipopolysaccharide (LPS+Ceft group). Another group of 6 calves received a combination of drug therapies that included CS 2 hr after administration of 0.9% NaCl (Comb group). A third group of 6 calves received the same combination therapy regimen 2 hr after intravenous injection of lipopolysaccharide (LPS+Comb group). Plasma concentrations of CS and all desfuroylceftiofur-related metabolites were determined using HPLC, and its pharmacokinetic properties were determined based on a two-compartment model. The peak concentration of CS in the LPS+Comb group occurred the earliest, and the clearance rate of CS was the highest in the Comb and LPS+Comb groups (P<0.05). The elimination half-life of CS in the LPS+Ceft group was longer than that in the Ceft and Comb groups (P<0.05). The results of this study indicate that combined therapies and endotoxemic status may alter the plasma pharmacokinetics of CS in calves.
Yazarlar (7)
1
Feray Altan
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
A. Er
4
Gul Cetin
5
Burak Dik
6
E. Yazar
7
M. Elmas
Anahtar Kelimeler
Calve
Ceftiofur
Endotoxemia
Pharmacokinetic
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Erzincan
Erzincan Turkey
Metrikler
8
Atıf
7
Yazar
4
Anahtar Kelime