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Determination of the embryotoxic effect of maropitant using an in ovo model

Polish Journal of Veterinary Sciences · Ocak 2022

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YÖKSİS Kayıtları
Determination of the embryotoxic effect of maropitant using an in ovo model
Polish Journal of Veterinary Sciences · 2022 SCI-Expanded
PROFESÖR ENVER YAZAR →
Determination of the embryotoxic effect of maropitant using an in ovo model
Polish Journal of Veterinary Sciences · 2022 SCI-Expanded
PROFESÖR ENVER YAZAR →
Determination of the embryotoxic effect of maropitant using an in ovo model
Polish Journal of Veterinary Sciences · 2022 SCI-Expanded
PROFESÖR ENVER YAZAR →
Determination of the embryotoxic effect of maropitant using an in ovo model
Polish Journal of Veterinary Sciences · 2022 SCI-Expanded
PROFESÖR ENVER YAZAR →

Makale Bilgileri

DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2022
Cilt / Sayfa25 · 357-359
DOI10.24425/pjvs.2022.141821
Scopus ID2-s2.0-85134855206
Erişim🔓 Açık Erişim
Özet The aim of this research was to determine the embryotoxic and teratogenic effects and lethal dose (LD50) of maropitant in ovo, using fertile chicken eggs. The study was designed in two stages, CHEST-I and CHEST-II. For CHEST-I, 210 fertile eggs were divided into seven equal groups; control, saline solution and 5 different doses of maropitant (10, 5, 2.5, 1.25, 0.625 mg/kg) injected groups. For CHEST-II, 150 fertile eggs were divided into five equal groups; control, saline solution and 3 different doses of maropitant (8, 6, 4 mg/kg)-injected groups. Eggs were opened on day 21 of incubation. Maropitant did not cause teratogenicity at any dose, while higher embryonic death rates were observed at doses above 4 mg/kg. The LD50dose of maropitant was determined as 7.24 mg/kg. In conclusion, maropitant should only be used after full consideration of risks and benefits in pregnancy.

Yazarlar (4)

1
Muhittin Uslu
ORCID: 0000-0002-9027-4229
2
Rahmi Canbar
ORCID: 0000-0001-7100-4437
3
G. Akcakavak
4
E. Yazar

Anahtar Kelimeler

embryotoxicity in ovo model Maropitant

Kurumlar

Bozok Üniversitesi
Yozgat Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey

Metrikler

2
Atıf
4
Yazar
3
Anahtar Kelime

Sistemimizdeki Yazarlar

EY
ENVER YAZAR
PROFESÖR

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