Scopus
YÖKSİS Eşleşti
Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluation
Industrial Crops and Products · Şubat 2019
YÖKSİS Kayıtları
Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluation
INDUSTRIAL CROPS AND PRODUCTS · 2019 SCI-Expanded
DOÇENT BAYRAM ATASAGUN →
Phenolic profiling and in vitro biological properties of two Lamiaceae species (Salvia modesta and Thymus argaeus): A comprehensive evaluation
INDUSTRIAL CROPS AND PRODUCTS · 2019 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Makale Bilgileri
DergiIndustrial Crops and Products
Yayın TarihiŞubat 2019
Cilt / Sayfa128 · 308-314
Scopus ID2-s2.0-85056752953
Özet
The genus Salvia and Thymus have gained much popularity as an alternative therapy in Turkish folk medicine for abdominal pain, cold, nausea, among others. Nonetheless, some species are yet to be further explored for their bioactivities. We investigated the biological activities of 3 extracts (dichloromethane, methanol, and water (decoction)) of Salvia modesta Boiss. and Thymus argaeus (Fisch. & C.A.Mey.) Boiss. & Balansa. based on antioxidant and enzyme inhibition along with the determination of polyphenolic content. Antioxidant potential was assessed using six assays namely: 2,2-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid), cupric ion reducing antioxidant capacity, ferric reducing antioxidant power, phosphomolybdenum, and metal chelating. Moreover, enzyme inhibition activities of the extracts were studied against acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-amylase, and α-glucosidase. Results revealed that the decoction of both plants was the strongest antioxidants. The methanol extracts displayed the highest tyrosinase inhibition while the dichloromethane extracts of both plants were the most effective butyrylcholinesterase and α-glucosidase inhibitors. In addition, the total phenolic and total flavonoid content was highest in the decoction and methanolic extract of Thymus argaeus, respectively. The most abundant phenolic compound was rosmarinic acid (6574 μg/g and 5390 μg/g in T. argaeus and S. modesta methanolic extracts, respectively). PASS prediction analysis revealed that chlorogenic acid showed the highest Pa value for antioxidant activity (0.809) including the mechanism of free radical scavenging (0.856), while rosmarinic acid showed the highest Pa value (0.798) for antidiabetic activity. To conclude, both Salvia modesta and Thymus argaeus can be regarded as new sources of antioxidants and enzyme inhibitors to manage oxidative stress and their complications.
Yazarlar (7)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Bayram Atasagun
3
Muhammad Zakariyyah Aumeeruddy
4
Hammad Saleem
5
Adriano Mollica
6
Mir Babak Bahadori
7
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Antioxidant
Enzyme inhibition
Phytochemical
Salvia modesta
Thymus argaeus
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Monash University Malaysia
Bandar Sunway Malaysia
Research Center for Pharmaceutical Nanotechnology
Tabriz Iran
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
University of Veterinary and Animal Sciences, Lahore
Lahore Pakistan
Metrikler
35
Atıf
7
Yazar
5
Anahtar Kelime