Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Pharmacokinetic disposition of enrofloxacin in brown trout (Salmo trutta fario) after oral and intravenous administrations
Aquaculture · Ekim 2009
YÖKSİS Kayıtları
Pharmacokinetic disposition of enrofloxacin in brown trout Salmo trutta fario after oral and intravenous administrations
Aquaculture · 2009 SCI-Expanded 18 atıf
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
2019 ISSN: 0044-8486 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
2019 ISSN: 0044-8486 SCI
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetic/pharmacodynamic integration of marbofloxacin after oral and intravenous administration in rainbow trout (Oncorhynchus mykiss)
2020 ISSN: 0044-8486 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration
2020 ISSN: 0044-8486 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetic disposition of enrofloxacin in brown trout Salmo trutta fario after oral and intravenous administrations
2009 ISSN: 00448486 SCI-Expanded 18 atıf
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
Dergi
Aquaculture
ISSN00448486
Yayın TarihiEkim 2009
Cilt / Sayfa295 · 142-144
Scopus ID2-s2.0-68749118128
Özet
In this study, the pharmacokinetic profile of enrofloxacin (EF) and its major metabolite, ciprofloxacin (CF), were investigated in brown trout (Salmo trutta fario) (n = 150) after intravenous (i.v.) and oral (p.o.) administrations of a single dose of 10 mg kg- 1 body weight (b.w.) at 10 °C. The plasma concentrations of the drugs were determined by high-performance liquid chromatography (HPLC-UV) from 0.08 to 120 h. Pharmacokinetic parameters were described by the two-compartment open model for intravenous and oral administrations, respectively. After intravenous administration, the elimination half-life (t1/2β), apparent volume of distribution at steady-state (Vss) and total body clearance (Cltot) of enrofloxacin were 19.14 ± 1.51 h, 3.40 ± 0.18 L kg- 1 and 0.14 ± 0.01 L kg h- 1, respectively. After oral administration, the maximum plasma concentration (Cmax), time of maximum concentration (tmax) and bioavailability (F%) were 2.30 ± 0.08 μg mL- 1, 8 h and 78 ± 4%, respectively. Ciprofloxacin was not detected in the present study. The elimination half-life for enrofloxacin following oral administration was longer than values calculated for other animals. After oral administration, the mean plasma concentration was well above the minimum inhibitory concentrations (MICs)-that is, > 0.5 μg mL- 1 at 36 h-for most gram-negative fish pathogens. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in brown trout (S. trutta fario) using oral administration of 10 mg kg- 1 body weight; therefore, it may be effective in the therapy for brown trout diseases. © 2009 Elsevier B.V. All rights reserved.
Yazarlar (5)
1
Feride Koç
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
Muhammed Atamanalp
4
Ilyas Tumer
5
G. Kaban
Anahtar Kelimeler
Antibiotic
Enrofloxacin
Fish
Pharmacokinetic
Plasma
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Pendik Veterinary Control Institute
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Aquaculture
Q1
SJR Skoru1,096
H-Index222
YayıncıElsevier B.V.
ÜlkeNetherlands
Aquatic Science (Q1)
Metrikler
51
Atıf
5
Yazar
5
Anahtar Kelime