Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics of meloxicam in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections
American Journal of Veterinary Research · Mayıs 2016
YÖKSİS Kayıtları
Pharmacokinetics of meloxicam in red eared slider turtles Trachemys scripta elegans after single intravenous and intramuscular injections
American Journal of Veterinary Research · 2016 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of meloxicam in red eared slider turtles Trachemys scripta elegans after single intravenous and intramuscular injections
American Journal of Veterinary Research · 2016 SCI
Prof. Dr. BURAK DİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Pharmacokinetics of meloxicam in red eared slider turtles Trachemys scripta elegans after single intravenous and intramuscular injections
2016 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of meloxicam in red eared slider turtles Trachemys scripta elegans after single intravenous and intramuscular injections
2016 ISSN: 0002-9645 SCI
Prof. Dr. BURAK DİK →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep
2019 ISSN: 0002-9645 SCI
Prof. Dr. KAMİL ÜNEY →
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea
2020 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. FATİH HATİPOĞLU →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep
2019 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. AYŞE ER →
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea
2020 ISSN: 0002-9645 SCI-Expanded Q3
Prof. Dr. MAHMUT OK →
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea
2020 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2 cyclosporine for treatment of dogs with keratoconjunctivitis sicca
2002 ISSN: 0002-9645 SSCI
Prof. Dr. İLHAMİ ÇELİK →
Biomarkers of infectious pneumonia in naturally infected calves
2022 ISSN: 0002-9645 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
Histological Characteristics and Lokal Cellular Immunity of the Gland of the Third Eyelid After Topical Ophthalmic Administration of 2% Cyclosporine for Treatment of Dogs with Keratoconjunctivitis sicca
2002 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. FAHRETTİN ALKAN →
Makale Bilgileri
ISSN00029645
Yayın TarihiMayıs 2016
Cilt / Sayfa77 · 439-444
Scopus ID2-s2.0-84964461860
Özet
OBJECTIVE To determine the pharmacokinetics of meloxicam after single IV and IM injections in red-eared slider turtles (Trachemys scripta elegans). ANIMALS 8 healthy red-eared slider turtles. PROCEDURES Turtles received 1 dose of meloxicam (0.2 mg/kg) IV or IM (4 turtles/route), a 30-day washout period was provided, and then turtles received the same dose by the opposite route. Blood samples were collected at predetermined times for measurement of plasma meloxicam concentration. Pharmacokinetic values for each administration route were determined with a 2-compartment open model approach. RESULTS For IV administration, mean ± SD values of major pharmacokinetic variables were 1.02 ± 0.41 hours for distribution half-life, 9.78 ± 2.23 hours for elimination half-life, 215 ± 32 mL/kg for volume of distribution at steady state, 11.27 ± 1.44μg•h/mL for area under the plasma concentration versus time curve, and 18.00 ± 2.32 mL/h/kg for total body clearance. For IM administration, mean values were 0.35 ± 0.06 hours for absorption half-life, 0.72 ± 0.06 μg/mL for peak plasma concentration, 1.5 ± 0.0 hours for time to peak concentration, 3.73 ± 2.41 hours for distribution half-life, 13.53 ± 1.95 hours for elimination half-life, 11.33 ± 0.92μg•h/mL for area under the plasma concentration versus time curve, and 101 ± 6% for bioavailability. No adverse reactions were detected. CONCLUSIONS AND CLINICAL RELEVANCE Long half-life, high bioavailability, and lack of immediate adverse reactions of meloxicam administered IM at 0.2 mg/kg suggested the possibility of safe and effective clinical use in turtles.
Yazarlar (5)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
Feray Altan
3
Mohamed Aboubakr
4
Gul Cetin
5
Burak Dik
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Faculty of Veterinary Medicine Benha University
Benha Egypt
University of Selcuk
Egypt
Scimago Dergi (ISSN Eşleşmesi)
American Journal of Veterinary Research
Q2
OA
SJR Skoru0,443
H-Index109
YayıncıAmerican Veterinary Medical Association
ÜlkeUnited States
Veterinary (miscellaneous) (Q2)
Medicine (miscellaneous) (Q3)
Metrikler
32
Atıf
5
Yazar