Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
Small Ruminant Research · Şubat 2018
YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
Small Ruminant Research · 2018 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The effects of different silage additives on rumen protozoan number and volatile fatty acid concentration in sheep fed corn silage
2003 ISSN: 09214488 SCI-Expanded 31 atıf
Prof. Dr. NURCAN DÖNMEZ →
Relationship of blood and seminal plasma ceruloplasmin copper iron and cadmium concentrations with sperm quality in Merino rams
2015 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effect of anti oxidants and oxidative stress parameters on ram semen after the freeze thawing process
2008 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effects of anti oxidant additives on microscopic and oxidative parameters of Angora goat semen following the freeze thawing process
2008 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Protective effect of taurine glutathione and trehalose on the liquid storage of ram semen
2007 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Comparison of the effects of glutamine and an amino acid solution on post thawed ram sperm parameters lipid peroxidation and anti oxidant activities
2009 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
The effect of antioxidants on post thawed Angora goat Capra hircus ancryrensis sperm parameters lipid peroxidation and antioxidant activities
2010 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Ergothioneine attenuates the DNA damage of post thawed Merino ram sperm
2012 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Ergothioneine attenuates the DNA damage of post thawed Merino ram sperm
2012 ISSN: 09214488 SCI-Expanded 1 atıf
Prof. Dr. NURİ BAŞPINAR →
Relationship of blood and seminal plasma ceruloplasmin copper iron and cadmium concentrations with sperm quality in merino rams
2015 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
The effect of 12 successive blood passages on the virulence of Babesia ovis in splenectomized lambs A preliminary study
2014 ISSN: 09214488 SCI-Expanded
Prof. Dr. NERMİN IŞIK USLU →
Lipolysis in Tulum cheese produced from raw and pasteurized goats milk during ripening
2014 ISSN: 09214488 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Attenuating the endotoxin induced acute phase response by pentoxifylline in comparison with dexamethasone and ketoprofen in sheep
2015 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. MEHMET MADEN →
Investigation of interferon tau stimulated genes ISGs simultaneously in the endometrium corpus luteum CL and peripheral blood leukocytes PBLs in the preluteolytic stage of early pregnancy in ewes
2016 ISSN: 09214488 SCI-Expanded Q2
Dr. Öğr. Üyesi GONCA SÖNMEZ →
Rapid diagnosis of ovine Brucella Campylobacter and Salmonella infections from fetal stomach contents by coagglutination test
2002 ISSN: 09214488 SSCI
Prof. Dr. OSMAN ERGANİŞ →
Influence of lycopene and cysteamine on sperm and oxidative stress parameters during liquid storage of ram semen at 5 degrees C
2016 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep
2019 ISSN: 0921-4488 SCI
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
Dergi
Small Ruminant Research
ISSN09214488
Yayın TarihiŞubat 2018
Cilt / Sayfa159 · 5-10
Scopus ID2-s2.0-85037992216
Özet
In this study, the pharmacokinetic disposition and bioavailability of marbofloxacin (MB) were determined in lambs after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at a dose of 3 mg/kg. The plasma concentration of MB was measured using high-performance liquid chromatography-UV, and the pharmacokinetic parameters were analyzed using a non-compartmental analysis. Following IV, IM, and SC administrations, the mean terminal half-life (t1/2ʎz) was 11.48, 12.64, and 24.86 h, respectively, and the mean residence time (MRT) was 7.27, 7.81, and 10.11 h, respectively. The bioavailability (F) was 96.01 and 126.39%, after IM and SC administration, respectively. This study showed that SC administration of MB at a dose of 3 mg/kg exhibited flip-flop pharmacokinetics in lambs. These results suggested that MB could be useful in the treatment of severe systemic infections, such as those with M. haemolytica (MIC = 0.035 μg/mL), in lambs since high AUC0-24/MIC and Cmax/MIC ratios were achieved after IV and IM administration at 3 mg/kg. However, MB administration (3 mg/kg) via the IV, IM, and SC routes might not be effective in the treatment of respiratory infections caused by organisms with MIC90 value in lambs.
Yazarlar (5)
1
Feray Altan
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
O. Atik
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Fluoroquinolones
Lamb
Marbofloxacin
Pharmacokinetics
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Small Ruminant Research
Q2
SJR Skoru0,432
H-Index106
YayıncıElsevier B.V.
ÜlkeNetherlands
Animal Science and Zoology (Q2)
Food Animals (Q2)
Metrikler
6
Atıf
5
Yazar
4
Anahtar Kelime