Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
Small Ruminant Research · Aralık 2018
YÖKSİS Kayıtları
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
SMALL RUMINANT RESEARCH · 2018 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
Small Ruminant Research · 2018 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The effects of different silage additives on rumen protozoan number and volatile fatty acid concentration in sheep fed corn silage
2003 ISSN: 09214488 SCI-Expanded 31 atıf
Prof. Dr. NURCAN DÖNMEZ →
Relationship of blood and seminal plasma ceruloplasmin copper iron and cadmium concentrations with sperm quality in Merino rams
2015 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effect of anti oxidants and oxidative stress parameters on ram semen after the freeze thawing process
2008 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effects of anti oxidant additives on microscopic and oxidative parameters of Angora goat semen following the freeze thawing process
2008 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Protective effect of taurine glutathione and trehalose on the liquid storage of ram semen
2007 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Comparison of the effects of glutamine and an amino acid solution on post thawed ram sperm parameters lipid peroxidation and anti oxidant activities
2009 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
The effect of antioxidants on post thawed Angora goat Capra hircus ancryrensis sperm parameters lipid peroxidation and antioxidant activities
2010 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Ergothioneine attenuates the DNA damage of post thawed Merino ram sperm
2012 ISSN: 09214488 SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Ergothioneine attenuates the DNA damage of post thawed Merino ram sperm
2012 ISSN: 09214488 SCI-Expanded 1 atıf
Prof. Dr. NURİ BAŞPINAR →
Relationship of blood and seminal plasma ceruloplasmin copper iron and cadmium concentrations with sperm quality in merino rams
2015 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
The effect of 12 successive blood passages on the virulence of Babesia ovis in splenectomized lambs A preliminary study
2014 ISSN: 09214488 SCI-Expanded
Prof. Dr. NERMİN IŞIK USLU →
Lipolysis in Tulum cheese produced from raw and pasteurized goats milk during ripening
2014 ISSN: 09214488 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Attenuating the endotoxin induced acute phase response by pentoxifylline in comparison with dexamethasone and ketoprofen in sheep
2015 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. MEHMET MADEN →
Investigation of interferon tau stimulated genes ISGs simultaneously in the endometrium corpus luteum CL and peripheral blood leukocytes PBLs in the preluteolytic stage of early pregnancy in ewes
2016 ISSN: 09214488 SCI-Expanded Q2
Dr. Öğr. Üyesi GONCA SÖNMEZ →
Rapid diagnosis of ovine Brucella Campylobacter and Salmonella infections from fetal stomach contents by coagglutination test
2002 ISSN: 09214488 SSCI
Prof. Dr. OSMAN ERGANİŞ →
Influence of lycopene and cysteamine on sperm and oxidative stress parameters during liquid storage of ram semen at 5 degrees C
2016 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep
2019 ISSN: 0921-4488 SCI
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
Dergi
Small Ruminant Research
ISSN09214488
Yayın TarihiAralık 2018
Cilt / Sayfa169 · 108-112
Scopus ID2-s2.0-85050946317
Özet
The objective of this study was to evaluate the pharmacokinetics of CTX following intravenous administration of ascending doses in sheep. In this study, six clinically healthy Akkaraman sheep (2.4 ± 0.4 years and 50 ± 3 kg of body weight) were used. CTX was administered intravenously to each sheep at 20, 40, and 80 mg/kg doses in a crossover design with a 15-day washout period. Plasma concentrations of CTX were measured using the high-performance liquid chromatography-UV method. Pharmacokinetic parameters were calculated by non-compartmental analysis. CTX was well tolerated following administration at 20, 40, and 80 mg/kg doses. The elimination half-life following administration of 40 and 80 mg/kg doses were significantly longer than that of 20 mg/kg dose (P < 0.05). The volume of distribution at steady state was similar among the groups (P > 0.05). When compared to 20 mg/kg, dose-normalized AUC0–∞ at the 80 mg/kg dose significantly increased (P < 0.05). The relation between dose and AUC0–∞ was linear. Our study showed that CTX can be used at 12-h intervals for 20, 40, and 80 mg/kg doses to maintain T > minimum inhibitory concentration (MIC) of >40% for the treatment of infections caused by bacteria with MIC values ≤2, ≤4, and ≤16 μg/mL, respectively. This information may be helpful in adjusting the dosage regimen, but there is a need for future work.
Yazarlar (7)
1
D. Durna Corum
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
Feray Altan
4
H. Eser Faki
5
Emre Bahcivan
6
A. Er
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Ascending dose
Ceftriaxone
Pharmacokinetics
Sheep
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Kafkas Üniversitesi, Veteriner Fakültesi
Kars Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Small Ruminant Research
Q2
SJR Skoru0,432
H-Index106
YayıncıElsevier B.V.
ÜlkeNetherlands
Animal Science and Zoology (Q2)
Food Animals (Q2)
Metrikler
8
Atıf
7
Yazar
4
Anahtar Kelime