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Scopus YÖKSİS DOI Eşleşti SJR Q2

Pharmacokinetics and bioavailability of tolfenamic acid in sheep

Journal of Veterinary Pharmacology and Therapeutics · Aralık 2018

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YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of tolfenamic acid in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2018 SCI
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of tolfenamic acid in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2018 SCI
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of tolfenamic acid in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2018 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Plasma and synovial fluid pharmacokinetics of cefquinome following the administration of multiple doses in horses
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Plasma and synovial fluid pharmacokinetics of cefquinome following the administration of multiple doses in horses
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Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections
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Pharmacokinetics of cefquinome in red-eared slider turtles (<i>Trachemys scripta elegans<\/i>) after single intravenous and intramuscular injections
2017 ISSN: 0140-7783 SCI-Expanded Q2
Prof. Dr. MUAMMER ELMAS →
Pharmacokinetics and bioavailability of tolfenamic acid in sheep
2018 ISSN: 0140-7783 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
title Pharmacokinetics of cefquinome in red-eared slider turtles ( iTrachemys scripta elegans/i ) after single intravenous and intramuscular injections/title
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Determination of milk/plasma ratio and milk and plasma pharmacokinetics of amoxicillin after intramuscular administration in lactating cows
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Pharmacokinetics and bioavailability of tolfenamic acid in sheep
2018 ISSN: 0140-7783 SCI
Prof. Dr. AYŞE ER →
Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections
2018 ISSN: 01407783 SCI-Expanded
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Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans after single intravenous and intramuscular injections
2018 ISSN: 0140-7783 SCI
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Pharmacokinetics of cefquinome in red-eared slider turtles (Trachemys scripta elegans) after single intravenous and intramuscular injections
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Makale Bilgileri

Dergi Journal of Veterinary Pharmacology and Therapeutics
ISSN01407783
Yayın TarihiAralık 2018
Cilt / Sayfa41 · 871-877
DOI10.1111/jvp.12702
Scopus ID2-s2.0-85052510285
Özet The pharmacokinetics, bioavailability, and tolerability of tolfenamic acid (TA) were determined after treating sheep with TA via different routes and doses. This crossover study was carried out with a washout period of 15 days. In the study, 16 clinically healthy sheep were randomly assigned to two equal groups. In the first group (n = 8), animals received TA by intravenous (IV), intramuscular (IM), subcutaneous (SC), or oral (OR) routes at 2 mg/kg. In the second group (n = 8), TA was administered intravenously to each sheep at 2, 4, 8, and 16 mg/kg. Plasma samples were analyzed with a high-performance liquid chromatography assay. Noncompartmental pharmacokinetic analyses were used to evaluate the data. The area under the concentration–time curves (AUC0−∞), elimination half-life (t1/2ʎz), and the mean residence time (MRT) significantly differed among the administration routes at 2 mg/kg of TA. Following IM, SC, and OR administrations, TA demonstrated different peak concentrations (Cmax) and time to reach Cmax (Tmax), with a bioavailability of 163%, 127%, and 107%, respectively. The dose-normalized AUC0−∞ revealed a significant difference among the dose groups; however, the relationship between dose and AUC0−∞ was linear. Both t1/2ʎz and MRT increased depending on the dose. Although the total clearance (ClT) decreased depending on dose, the volume of distribution at steady-state (Vss) increased. Tolfenamic acid indicated a long half-life and high bioavailability following IM, SC, and OR administrations at 2 mg/kg. TA exhibited linear kinetics and was well tolerated by the animals, except at 16 mg/kg. Thus, TA may be used in different routes and doses (≤8 mg/kg) in sheep; however, further studies are needed to determine the clinical efficacy of TA during the inflammatory and painful conditions and the pharmacokinetics and safety of repeated administration in sheep.

Yazarlar (5)

1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
D. Durna Corum
3
A. Er
4
Ramazan Yildiz
5
Kamil Üney
ORCID: 0000-0002-8674-4873

Anahtar Kelimeler

bioavailability pharmacokinetics sheep tolerability tolfenamic acid

Kurumlar

Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Veterinary Pharmacology and Therapeutics
Q2
SJR Skoru0,386
H-Index70
YayıncıWiley-Blackwell Publishing Ltd
ÜlkeUnited Kingdom
Veterinary (miscellaneous) (Q2)
Pharmacology (Q3)
Dergi sayfasına git

Metrikler

30
Atıf
5
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

KÜ
KAMİL ÜNEY
Prof. Dr.

Hızlı Erişim

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