Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations
Food Additives and Contaminants Part A Chemistry Analysis Control Exposure and Risk Assessment · Aralık 2018
YÖKSİS Kayıtları
Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations
Food Additives Contaminants: Part A · 2018 SCI
Prof. Dr. AYŞE ER →
title Plasma and tissue disposition of danofloxacin in brown trout ( iSalmo trutta fario)/i after intravenous and intramuscular administrations/title
Food Additives Contaminants: Part A · 2018 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations
2018 ISSN: 1944-0049 SCI
Prof. Dr. AYŞE ER →
title Plasma and tissue disposition of danofloxacin in brown trout ( iSalmo trutta fario)/i after intravenous and intramuscular administrations/title
2018 ISSN: 1944-0049 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
title Pharmacokinetics, bioavailability and tissue residues of doxycycline in Japanese quails ( iCoturnix coturnix japonica/i ) after oral administration/title
2020 ISSN: 1944-0049 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations
2022 ISSN: 1944-0049 SCI Q2
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
Dergi
Food Additives and Contaminants Part A Chemistry Analysis Control Exposure and Risk Assessment
ISSN19440049
Yayın TarihiAralık 2018
Cilt / Sayfa35 · 2340-2347
Scopus ID2-s2.0-85055480752
Özet
Plasma and muscle pharmacokinetics of danofloxacin were investigated after 10 mg/kg intravenous (IV, caudal vein) and intramuscular (IM, right epaxial muscles) administrations in 168 healthy brown trout (Salmo trutta fario) at 10°C–13°C. High-performance liquid chromatography was used to determine its plasma and muscle concentrations. Pharmacokinetic parameters were analysed with a non-compartmental model. After IV administration, elimination half-life (t 1/2ʎz ), area under the concentration–time curve (AUC 0–∞ ), mean residence time (MRT 0–∞ ), volume of distribution at steady state, total body clearance in plasma and AUC Muscle /AUC Plasma ratio were 22.22 h, 140.66 h*µg/mL, 23.15 h, 2.28 L/kg, 0.07 L/h/kg and 3.79, respectively. After IM administration, t 1/2ʎz , AUC 0–∞ , MRT 0–∞ , peak concentration (C max ), time to reach C max , bioavailability in plasma and AUC Muscle /AUC Plasma ratio were 28.28 h, 84.39 h*µg/mL, 37.31 h, 4.79 µg/mL, 1 h, 59.99% and 8.46, respectively. Danofloxacin exhibited long t 1/2ʎz and good bioavailability after IM administration. Therefore, 10 mg/kg IM administration of danofloxacin in brown trout can provide AUC 0–24 /MIC of > 125 and C max /MIC of > 10 to treat diseases caused by susceptible bacteria with ≤ 0.336 µg/mL MIC.
Yazarlar (5)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
D. Durna Corum
3
A. Er
4
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
brown trout
Danofloxacin
pharmacokinetics
tissue
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Food Additives and Contaminants - Part A
Q2
SJR Skoru0,526
H-Index71
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Chemistry (miscellaneous) (Q2)
Food Science (Q2)
Public Health, Environmental and Occupational Health (Q2)
Health, Toxicology and Mutagenesis (Q3)
Medicine (miscellaneous) (Q3)
Toxicology (Q3)
Metrikler
22
Atıf
5
Yazar
5
Anahtar Kelime