Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
Aquaculture · Şubat 2019
YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
AQUACULTURE · 2019 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
AQUACULTURE · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
2019 ISSN: 0044-8486 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of ceftriaxone in brown trout (Salmo trutta fario) after intravenous and intramuscular administration
2019 ISSN: 0044-8486 SCI
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetic/pharmacodynamic integration of marbofloxacin after oral and intravenous administration in rainbow trout (Oncorhynchus mykiss)
2020 ISSN: 0044-8486 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration
2020 ISSN: 0044-8486 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetic disposition of enrofloxacin in brown trout Salmo trutta fario after oral and intravenous administrations
2009 ISSN: 00448486 SCI-Expanded 18 atıf
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
Dergi
Aquaculture
ISSN00448486
Yayın TarihiŞubat 2019
Cilt / Sayfa500 · 272-277
Scopus ID2-s2.0-85055101200
Özet
Ceftriaxone (CTX) is a third-generation cephalosporin that has proven to be effective in the treatment of infections caused by a wide range of gram-positive and gram-negative microorganisms. This study aimed to determine the plasma and muscle pharmacokinetics of CTX after its administration via the intravenous (IV) and intramuscular (IM) routes to brown trout (Salmo trutta fario) at temperatures of 10 °C–13 °C. In total, 140 healthy brown trout (body weight, 245 ± 38 g) were used. The brown trout received single IV and IM injections of CTX at 25 mg/kg. The IV doses were injected into the caudal vein, whereas the IM doses were injected into the right epaxial muscles. The plasma and muscle tissue concentrations of CTX were measured using high-performance liquid chromatography. Pharmacokinetic parameters were calculated using noncompartmental methods. Following the IV administration of CTX, the elimination half-life (t1/2ʎz), volume of distribution at steady state, total body clearance, and area under the concentration–time curve (AUC0–72) in plasma were 5.83 h, 0.09 L/kg, 0.02 L/h/kg, and 1079.46 h*μg/mL, respectively. After the IM administration of CTX, plasma t1/2ʎz, peak plasma concentration (Cmax), time to reach Cmax, and bioavailability were 22.78 h, 87.92 μg/mL, 0.5 h, and 27.19%, respectively. The AUCMuscle/AUCPlasma ratio following the IV administration was 0.02 and that following the IM administration was 0.04. CTX exhibited low bioavailability and prolonged t1/2ʎz after the IM administration. The prolonged t1/2ʎz of CTX could thus be beneficial in brown trout. Nevertheless, future studies that aim to determine the clinical efficacy and pharmacokinetics after repeated administration of CTX are warranted.
Yazarlar (5)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
A. Er
3
D. Durna Corum
4
O. Atik
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Bioavailability
Brown trout
Ceftriaxone
Pharmacokinetics
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Aquaculture
Q1
SJR Skoru1,096
H-Index222
YayıncıElsevier B.V.
ÜlkeNetherlands
Aquatic Science (Q1)
Metrikler
19
Atıf
5
Yazar
4
Anahtar Kelime