Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep
Small Ruminant Research · Mayıs 2019
YÖKSİS Kayıtları
Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep
SMALL RUMINANT RESEARCH · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The effects of different silage additives on rumen protozoan number and volatile fatty acid concentration in sheep fed corn silage
2003 ISSN: 09214488 SCI-Expanded 31 atıf
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Relationship of blood and seminal plasma ceruloplasmin copper iron and cadmium concentrations with sperm quality in Merino rams
2015 ISSN: 09214488 SCI-Expanded
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Effect of anti oxidants and oxidative stress parameters on ram semen after the freeze thawing process
2008 ISSN: 09214488 SCI-Expanded
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Effects of anti oxidant additives on microscopic and oxidative parameters of Angora goat semen following the freeze thawing process
2008 ISSN: 09214488 SCI-Expanded
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Protective effect of taurine glutathione and trehalose on the liquid storage of ram semen
2007 ISSN: 09214488 SCI-Expanded
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Comparison of the effects of glutamine and an amino acid solution on post thawed ram sperm parameters lipid peroxidation and anti oxidant activities
2009 ISSN: 09214488 SCI-Expanded
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The effect of antioxidants on post thawed Angora goat Capra hircus ancryrensis sperm parameters lipid peroxidation and antioxidant activities
2010 ISSN: 09214488 SCI-Expanded
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Ergothioneine attenuates the DNA damage of post thawed Merino ram sperm
2012 ISSN: 09214488 SCI-Expanded
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Ergothioneine attenuates the DNA damage of post thawed Merino ram sperm
2012 ISSN: 09214488 SCI-Expanded 1 atıf
Prof. Dr. NURİ BAŞPINAR →
Relationship of blood and seminal plasma ceruloplasmin copper iron and cadmium concentrations with sperm quality in merino rams
2015 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
The effect of 12 successive blood passages on the virulence of Babesia ovis in splenectomized lambs A preliminary study
2014 ISSN: 09214488 SCI-Expanded
Prof. Dr. NERMİN IŞIK USLU →
Lipolysis in Tulum cheese produced from raw and pasteurized goats milk during ripening
2014 ISSN: 09214488 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Attenuating the endotoxin induced acute phase response by pentoxifylline in comparison with dexamethasone and ketoprofen in sheep
2015 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. MEHMET MADEN →
Investigation of interferon tau stimulated genes ISGs simultaneously in the endometrium corpus luteum CL and peripheral blood leukocytes PBLs in the preluteolytic stage of early pregnancy in ewes
2016 ISSN: 09214488 SCI-Expanded Q2
Dr. Öğr. Üyesi GONCA SÖNMEZ →
Rapid diagnosis of ovine Brucella Campylobacter and Salmonella infections from fetal stomach contents by coagglutination test
2002 ISSN: 09214488 SSCI
Prof. Dr. OSMAN ERGANİŞ →
Influence of lycopene and cysteamine on sperm and oxidative stress parameters during liquid storage of ram semen at 5 degrees C
2016 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics and bioavailability of marbofloxacin in lambs following administration of intravenous, intramuscular and subcutaneous
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of ceftriaxone following single ascending intravenous doses in sheep
2018 ISSN: 0921-4488 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of marbofloxacin following intramuscular administration at different doses in sheep
2019 ISSN: 0921-4488 SCI
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
Dergi
Small Ruminant Research
ISSN09214488
Yayın TarihiMayıs 2019
Cilt / Sayfa174 · 88-91
Scopus ID2-s2.0-85063418981
Özet
The pharmacokinetics of marbofloxacin (MBX) was determined following the intramuscular administration at the doses of 2, 4, 6, and 10 mg/kg in twenty-four healthy sheep. In parallel design, sheep were randomized to 2, 4, 6, and 10 mg/kg dose groups of six animals per group. High performance liquid chromatography method for determination of MBX in sheep plasma was used. Pharmacokinetic parameters were calculated by a non-compartmental method. The dose-normalized the area under the concentration-versus-time curve (AUC 0-∞ ) and dose-normalized maximum plasma concentration (C max ) in 10 mg/kg dose group were significantly higher than other dose groups. The elimination half-life (t 1/2λz ) of marbofloxacin in 10 mg/kg dose group was significantly longer than other dose groups. MBX exhibited dose-proportional pharmacokinetics and was well tolerated after 2, 4, 6 and 10 mg/kg doses in sheep. The 2, 4, 6, and 10 mg/kg doses of MBX could be administered in the treatment of infections caused by susceptible pathogens in sheep. However, additional studies are needed to identify whether MBX is efficient in sheep of naturally infected with susceptible bacteria.
Yazarlar (5)
1
Feray Altan
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
Semih Altan
ORCID: 0000-0003-3158-3678
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Different dose
Marbofloxacin
Pharmacokinetics
Sheep
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Small Ruminant Research
Q2
SJR Skoru0,432
H-Index106
YayıncıElsevier B.V.
ÜlkeNetherlands
Animal Science and Zoology (Q2)
Food Animals (Q2)
Metrikler
4
Atıf
5
Yazar
4
Anahtar Kelime