Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)
Journal of Veterinary Medical Science · Mayıs 2019
YÖKSİS Kayıtları
Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)
Journal of Veterinary Medical Science · 2019 SCI-Expanded
PROFESÖR AYŞE ER →
Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)
JOURNAL OF VETERINARY MEDICAL SCIENCE · 2019 SCI
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Medical Science
Yayın TarihiMayıs 2019
Cilt / Sayfa81 · 753-757
Scopus ID2-s2.0-85067099075
Erişim🔓 Açık Erişim
Özet
This study aimed to investigate the pharmacokinetics of danofloxacin in red-eared slider turtle (Trachemys scripta elegans) following a single intravenous (IV) and intramuscular (IM) administrations of 6 mg/kg, using a two-way crossover study with 30-day washout period. Eight clinically healthy red-eared slider turtle weighing 410-600 g (mean 490 g) were used for the study. Danofloxacin concentrations were measured using the reversed-phase high-performance liquid chromatography. The plasma concentration-time data were evaluated by a non-compartmental method. After IV administration, the elimination half-life (t1/2ʎz), mean residence time (MRT0-∞), area under the concentration-time curve (AUC0-∞), volume of distribution at steady state and total body clearance in plasma were 24.17 hr, 30.64 hr, 143.31 hr·μg/ml, 1.29 l/kg and 0.04 l/hr/kg, respectively. Following IM administration, t1/2ʎz, MRT0-∞AUC0-∞,peak concentration (Cmax), time to reach Cmax, and bioavailability in plasma were 32.00 hr, 41.15 hr, 198.23 hr·μg/ml, 8.75 μg/ml, 1.5 hr and 139.89%, respectively. Danofloxacin has clinically superior pharmacokinetic properties, including the complete IM absorption, slow elimination and wide volume of distribution in redeared slider turtles. However, further pharmacokinetics/pharmacodynamics studies are necessary for the treatment of diseases caused by susceptible bacteria with known minimum inhibitory concentration values in red-eared slider turtles.
Yazarlar (6)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
D. Durna Corum
3
Feray Altan
4
A. Er
5
Gul Cetin
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Bioavailability
Danofloxacin
Pharmacokinetics
Red-eared slider turtles
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Erzincan
Erzincan Turkey
Metrikler
8
Atıf
6
Yazar
4
Anahtar Kelime