Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep
American Journal of Veterinary Research · Temmuz 2019
YÖKSİS Kayıtları
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep
AMERICAN JOURNAL OF VETERINARY RESEARCH · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Pharmacokinetics of meloxicam in red eared slider turtles Trachemys scripta elegans after single intravenous and intramuscular injections
2016 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics of meloxicam in red eared slider turtles Trachemys scripta elegans after single intravenous and intramuscular injections
2016 ISSN: 0002-9645 SCI
Prof. Dr. BURAK DİK →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep
2019 ISSN: 0002-9645 SCI
Prof. Dr. KAMİL ÜNEY →
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea
2020 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. FATİH HATİPOĞLU →
Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after intravenous administration of increasing doses to sheep
2019 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. AYŞE ER →
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea
2020 ISSN: 0002-9645 SCI-Expanded Q3
Prof. Dr. MAHMUT OK →
Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea
2020 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Histologic characteristics and local cellular immunity of the gland of the third eyelid after topical ophthalmic administration of 2 cyclosporine for treatment of dogs with keratoconjunctivitis sicca
2002 ISSN: 0002-9645 SSCI
Prof. Dr. İLHAMİ ÇELİK →
Biomarkers of infectious pneumonia in naturally infected calves
2022 ISSN: 0002-9645 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
Histological Characteristics and Lokal Cellular Immunity of the Gland of the Third Eyelid After Topical Ophthalmic Administration of 2% Cyclosporine for Treatment of Dogs with Keratoconjunctivitis sicca
2002 ISSN: 0002-9645 SCI-Expanded
Prof. Dr. FAHRETTİN ALKAN →
Makale Bilgileri
ISSN00029645
Yayın TarihiTemmuz 2019
Cilt / Sayfa80 · 702-708
Scopus ID2-s2.0-85068881781
Özet
OBJECTIVE To determine the pharmacokinetics of pentoxifylline (PTX) and its 5-hydroxyhexyl metabolite (M-I) after IV administration of increasing doses of PTX to sheep. ANIMALS 6 healthy adult Merino sheep. PROCEDURES Each sheep received 10-, 20-, and 40-mg/kg doses of PTX, IV, with a 15-day washout period between doses. Blood samples were collected before and at predetermined times after administration of each dose to determine plasma PTX and M-I concentrations by high-performance liquid chromatography. Pharmacokinetic parameters for PTX and M-I were estimated by noncompartmental analysis. RESULTS No adverse effects were observed after administration of the 10- and 20-mg/kg doses. Following administration of the 40-mg/kg dose, all sheep developed tachycardia and hypersalivation and appeared agitated for approximately 4 hours. Plasma PTX concentrations considered therapeutic in other species were achieved in all sheep after administration of all 3 doses. Pharmacokinetic parameters for PTX and M-I varied in a dose-dependent linear manner. For PTX, the mean area under the concentration-time curve (AUC), elimination half-life, and volume of distribution increased with dose and ranged from 15.67 to 94.66 h.µg/mL, 0.68 to 0.91 hours, and 0.55 to 0.66 L/kg, respectively, whereas clearance decreased with dose and ranged from 0.42 to 0.64 L/h/kg. The mean ratio of the AUC for M-I to AUC for PTX ranged from 0.38 to 0.46. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that pharmacokinetic parameters for PTX and M-I varied in a dose-dependent linear manner in healthy sheep. Further studies are warranted to determine the therapeutic threshold and optimal dosage for PTX in sheep. (Am J Vet Res 2019;80:702-708).
Yazarlar (5)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
D. Durna Corum
3
O. Atik
4
A. Er
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
American Journal of Veterinary Research
Q2
OA
SJR Skoru0,443
H-Index109
YayıncıAmerican Veterinary Medical Association
ÜlkeUnited States
Veterinary (miscellaneous) (Q2)
Medicine (miscellaneous) (Q3)
Metrikler
7
Atıf
5
Yazar