Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans)
Veterinary Anaesthesia and Analgesia · Eylül 2019
YÖKSİS Kayıtları
Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans)
VETERINARY ANAESTHESIA AND ANALGESIA · 2019 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans)
VETERINARY ANAESTHESIA AND ANALGESIA · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans)
2019 ISSN: 1467-2987 SCI-Expanded
Prof. Dr. AYŞE ER →
Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans)
2019 ISSN: 1467-2987 SCI
Prof. Dr. KAMİL ÜNEY →
Pharmacokinetics and bioavailability of meloxicam in Pekin ducks following intravenous, intramuscular and oral administration
2023 ISSN: 1467-2987 SCI-Expanded Q2
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
ISSN14672987
Yayın TarihiEylül 2019
Cilt / Sayfa46 · 699-706
Scopus ID2-s2.0-85070088021
Özet
Objective: To determine the pharmacokinetics of tolfenamic acid (TA) after different routes of administration [intravenous (IV) and intramuscular (IM), 2 mg kg−1] and doses (IV, 2 and 4 mg kg−1) in red-eared slider turtles (Trachemys scripta elegans). Study design: Randomized experimental trial. Animals: Sixteen healthy red-eared slider turtles. Methods: Turtles were randomly assigned to two groups (n = 8 each). Group 1 received TA at a dose of 2 mg kg−1 IV and then IM, after a washout period of 30 days. Group 2 received 4 mg kg−1 TA IV. A noncompartmental analysis was used to calculate pharmacokinetic variables. Results: No local and/or systemic adverse drug effects were observed in any turtle. Elimination half-life and mean residence time following IM administration at 2 mg kg−1 were significantly longer than those following IV administration. The bioavailability following IM administration was complete. The area under the plasma concentration-time curve, elimination half-life, mean residence time and total clearance were significantly different between the dose groups. Conclusions and clinical relevance: The absence of adverse reactions in the turtles of the study of TA along with the favourable pharmacokinetic properties (the long half-life and the complete bioavailability) of TA administered at the single doses of 2 and 4 mg kg−1 suggest the possibility of its effective use in turtles. However, further studies are required to establish a multiple dosage regimen of TA and to evaluate the clinical efficacy of administering TA.
Yazarlar (5)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
O. Atik
3
D. Durna Corum
4
A. Er
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
pharmacokinetics
red-eared slider turtles
tolfenamic acid
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Veterinary Anaesthesia and Analgesia
Q2
SJR Skoru0,516
H-Index71
YayıncıElsevier B.V.
ÜlkeNetherlands
Veterinary (miscellaneous) (Q2)
Metrikler
17
Atıf
5
Yazar
4
Anahtar Kelime