Scopus
YÖKSİS Eşleşti
Pharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)
Journal of Veterinary Pharmacology and Therapeutics · Kasım 2019
YÖKSİS Kayıtları
Pharmacokinetics of levamisole in the red‐eared slider turtles (Trachemys scripta elegans)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2019 SCI-Expanded
PROFESÖR AYŞE ER →
Pharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2019 SCI
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiKasım 2019
Cilt / Sayfa42 · 654-659
Scopus ID2-s2.0-85063720229
Özet
The pharmacokinetics and bioavailability of levamisole were determined in red-eared slider turtles after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration. Nine turtles received levamisole (10 mg/kg) by each route in a three-way crossover design with a washout period of 30 days. Blood samples were collected at time 0 (pretreatment), and at 0.25, 0.5, 1, 1.5, 3, 6, 9, 12, 18, 24, 36, and 48 hr after drug administration. Plasma levamisole concentrations were determined by a high-performance liquid chromatography assay. Data were analyzed by noncompartmental methods. The mean elimination half-life was 5.00, 7.88, and 9.43 hr for IV, IM, and SC routes, respectively. The total clearance and volume of distribution at steady state for the IV route were 0.14 L hr−1 kg−1 and 0.81 L/kg, respectively. For the IM and SC routes, the peak plasma concentration was 9.63 and 10.51 μg/ml, respectively, with 0.5 hr of Tmax. The bioavailability was 93.03 and 115.25% for the IM and SC routes, respectively. The IM and SC route of levamisole, which showed the high bioavailability and long t1/2ʎz, can be recommended as an effective way for treating nematodes in turtles.
Yazarlar (6)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
D. Durna Corum
3
O. Atik
4
Feray Altan
5
A. Er
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
levamisole
pharmacokinetics
red-eared slider turtles
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
6
Yazar
4
Anahtar Kelime