Scopus
YÖKSİS DOI Eşleşti
SJR Q2
The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs
Tropical Animal Health and Production · Kasım 2019
YÖKSİS Kayıtları
The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs
TROPICAL ANIMAL HEALTH AND PRODUCTION · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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The effects of Mannheimia haemolytica and albendazole on marbofloxacin pharmacokinetics in lambs
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Prof. Dr. KAMİL ÜNEY →
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Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite following intravenous administration in cattle
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Makale Bilgileri
ISSN00494747
Yayın TarihiKasım 2019
Cilt / Sayfa51 · 2603-2610
Scopus ID2-s2.0-85068128991
Özet
The study aimed to define the effects of M. haemolytica and a single oral dose of albendazole on the single-dose pharmacokinetics of marbofloxacin in lambs. The pharmacokinetic–pharmacodynamic integration of marbofloxacin was applied to describe a 3 mg/kg intramuscular dose in lambs. The 6 healthy and 12 naturally infected with M. haemolytica lambs (Akkaraman, males weighing 10–15 kg and aged 2–3 months) were used in this study. In the marbofloxacin group, 6 healthy lambs received marbofloxacin. In the albendazole group after 2 weeks washout period, the same animals received marbofloxacin on 1 h after albendazole. In the diseased marbofloxacin group, 6 lambs naturally infected with M. haemolytica received marbofloxacin. In the diseased albendazole group, 6 lambs naturally infected with M. haemolytica received marbofloxacin on 1 h after albendazole. The marbofloxacin and albendazole were administered each as a single dose of 3 mg/kg intramuscular and 7.5 mg/kg oral, respectively, in the respective groups. Plasma concentration of marbofloxacin was measured with HPLC-UV and pharmacokinetic parameters were analyzed by non-compartmental model. Albendazole did not change the pharmacokinetic profiles of marbofloxacin in healthy and diseased lambs. However, M. haemolytica affected the pharmacokinetics of marbofloxacin in diseased lambs, AUC0–24/MIC90 ratio was not found to be higher than 125, but Cmax/MIC90 ratios was found to be higher than 10 for an MIC value of 0.25 μg/mL in all groups. The marbofloxacin dose described in this study may not be effective for the treatment of infections due to M. haemolytica in lambs, with MIC ≤ 0.25 μg/mL.
Yazarlar (6)
1
Feray Altan
2
Duygu Neval Sayin Ipek
3
Orhan Corum
ORCID: 0000-0003-3168-2510
4
Simten Yesilmen Alp
5
Polat Ipek
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Albendazole
Lamb
Mannheimia haemolytica
Marbofloxacin
Pharmacokinetics
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Tropical Animal Health and Production
Q2
SJR Skoru0,472
H-Index73
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Animal Science and Zoology (Q2)
Food Animals (Q2)
Metrikler
5
Atıf
6
Yazar
5
Anahtar Kelime