Scopus
YÖKSİS Eşleşti
Pharmacokinetics of tolfenamic acid after different administration routes in geese (Anser cygnoides)
Journal of Veterinary Pharmacology and Therapeutics · Mayıs 2021
YÖKSİS Kayıtları
Pharmacokinetics of tolfenamic acid after different administration routes in geese (\n Anser cygnoides\n )
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiMayıs 2021
Cilt / Sayfa44 · 381-387
Scopus ID2-s2.0-85100911812
Özet
The pharmacokinetics and bioavailability of tolfenamic acid were determined in geese (Anser cygnoides) following intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral administrations at 2 mg/kg dose. In this study, eight healthy geese (3.5 ± 0.5 kg) were used. The study was performed in four periods according to a crossover design with a 15-day washout period between two administrations. The plasma concentrations of tolfenamic acid were analyzed using HPLC-UV, and pharmacokinetic parameters were calculated by noncompartmental analysis. The elimination half-life was 1.73, 2.51, 2.34, and 2.31 hr for IV, IM, SC, and oral routes, respectively. The volume of distribution at steady state and total clearance after IV administration were 0.25 L/kg and 0.16 L hr−1 kg−1, respectively. The peak plasma concentrations of tolfenamic acid after IM, SC, and oral administrations were 4.89, 2.94, and 2.92 μg/ml at 0.25, 0.75, and 1 hr, respectively. The bioavailability was 87.91, 77.87, and 76.03% for the IM, SC, and oral routes, respectively. Tolfenamic acid, which exhibits the good bioavailability and plasma concentration following IM, SC, and oral administrations at 2 mg/kg dose, may be useful in the treatment of inflammatory disease conditions in geese.
Yazarlar (6)
1
Erdinc Turk
ORCID: 0000-0003-1735-1774
2
Ibrahim Ozan Tekeli
ORCID: 0000-0002-6845-2279
3
D. Durna Corum
4
Orhan Corum
ORCID: 0000-0003-3168-2510
5
Fatih Sakin
ORCID: 0000-0001-5377-0322
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
geese
pharmacokinetics
tolfenamic acid
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Metrikler
14
Atıf
6
Yazar
4
Anahtar Kelime