Scopus
YÖKSİS Eşleşti
Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (Coturnix coturnix japonica)
Journal of Veterinary Pharmacology and Therapeutics · Mayıs 2021
YÖKSİS Kayıtları
Pharmacokinetics of meloxicam, carprofen, and tolfenamic acid after intramuscular and oral administration in Japanese quails (\n Coturnix coturnix japonica\n )
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiMayıs 2021
Cilt / Sayfa44 · 388-396
Scopus ID2-s2.0-85104109443
Özet
The aim of this study was to determine the pharmacokinetics of meloxicam (MLX), carprofen (CRP), and tolfenamic acid (TA) in Japanese quails (Coturnix coturnix japonica) following intramuscular (IM) and oral administration at doses of 1, 10, and 2 mg/kg, respectively. A total of 72 quails were randomly divided into 3 equal groups as MLX, CRP, and TA. Each group was separated into two sub-groups that received IM and oral administration of each drug. Plasma concentrations of MLX, CRP, and TA were determined using HPLC-UV and analyzed by non-compartmental method. The t1/2ʎz and MRT of MLX, CRP, and TA after oral administration were similar to those after IM administration. The Vdarea/F of MLX, CRP, and TA after IM administration was 0.28, 2.05, and 0.20 L/kg. The Cl/F of MLX, CRP, and TA after IM administration was 0.12, 0.19, and 0.09 L/h/kg. MLX, CRP, and TA after oral administration showed significantly lower Cmax and longer Tmax compared with IM administration. The relative bioavailability of MLX, CRP, and TA following oral administration in quails was 76.13%, 61.46%, and 57.32%, respectively. The IM and oral route of MLX, CRP, and TA can be used for the treatment of various conditions in quails. However, further research is necessary to determine the pharmacodynamics and safety of MLX, CRP, and TA before use in quails.
Yazarlar (8)
1
Erdinc Turk
ORCID: 0000-0003-1735-1774
2
Ibrahim Ozan Tekeli
ORCID: 0000-0002-6845-2279
3
Orhan Corum
ORCID: 0000-0003-3168-2510
4
D. Durna Corum
5
Fatma Ceren Kirgiz
ORCID: 0000-0002-8454-5336
6
Gul Cetin
7
Dilek Arslan Atessahin
ORCID: 0000-0002-1528-9367
8
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
carprofen
meloxicam
pharmacokinetics
quails
tolfenamic acid
Kurumlar
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Cankiri Karatekin
Cankiri Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Metrikler
12
Atıf
8
Yazar
5
Anahtar Kelime