Scopus
YÖKSİS Eşleşti
Pharmacokinetics and bioavailability of furosemide in sheep
Journal of Veterinary Pharmacology and Therapeutics · Temmuz 2021
YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of furosemide in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiTemmuz 2021
Cilt / Sayfa44 · 657-662
Scopus ID2-s2.0-85097510066
Özet
The pharmacokinetics and bioavailability of furosemide were determined following intravenous (IV), intramuscular (IM), and subcutaneous (SC) administrations at 2.5 mg/kg dose in sheep. The study was conducted on six healthy sheep in a three-way, three-period, crossover pharmacokinetic design with a 15-day washout period. In first period, furosemide was randomly administered via IV to 2 sheep, IM to 2 sheep and SC to 2 sheep. In second and third periods, each sheep received furosemide via different routes of administration with the 15-day washout period. Plasma concentrations were determined using a high-performance liquid chromatography assay and analyzed by noncompartmental method. The mean total clearance and volume of distribution at steady state following IV administration were 0.24 L h-1 kg-1 and 0.17 L/kg, respectively. The elimination half-life was similar for all administration routes. The mean peak plasma concentrations of IM and SC administration were 10.33 and 3.18 μg/ml at 0.33 and 0.42 hr, respectively. The mean bioavailability of IM and SC administration was 97.91% and 37.98%, respectively. The IM injection of furosemide may be the alternative routes in addition to IV. However, further research is required to determine the effect of dose and route of administration on the clinical efficacy of furosemide in sheep.
Yazarlar (6)
1
D. Durna Corum
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
O. Atik
4
Gul Cetin
5
A. Zhunushova
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
furosemide
pharmacokinetics
sheep
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kastamonu University
Kastamonu Turkey
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
6
Yazar
4
Anahtar Kelime