Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Pharmacokinetics and bioavailability of carprofen in rainbow trout (Oncorhynchus mykiss) broodstock
Pharmaceutics · Temmuz 2021
YÖKSİS Kayıtları
Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Oncorhynchus mykiss) Broodstock
Pharmaceutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiPharmaceutics
Yayın TarihiTemmuz 2021
Cilt / Sayfa13
Scopus ID2-s2.0-85109515725
Erişim🔓 Açık Erişim
Özet
The aim of this study was to determine the pharmacokinetics of carprofen following intravenous (IV), intramuscular (IM) and oral routes to rainbow trout (Oncorhynchus mykiss) broodstock at temperatures of 10 ± 1.5◦C. In this study, thirty-six healthy rainbow trout broodstock (body weight, 1.45 ± 0.30 kg) were used. The plasma concentrations of carprofen were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using non-compartmental analysis. Carprofen was measured up to 192 h for IV route and 240 h for IM, and oral routes in plasma. The elimination half-life (t1/2λz) was 30.66, 46.11, and 41.08 h for IV, IM and oral routes, respectively. Carprofen for the IV route showed the total clearance of 0.02 L/h/kg and volume of distribution at steady state of 0.60 L/kg. For IM and oral routes, the peak plasma concentration (Cmax) was 3.96 and 2.52 µg/mL with the time to reach Cmax of 2 and 4 h, respectively. The bioavailability was 121.89% for IM route and 78.66% for oral route. The favorable pharmacokinetic properties such as the good bioavailability and long t1/2λz for IM and oral route of carprofen suggest the possibility of its effective use for the treatment of various conditions in broodstock.
Yazarlar (4)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
D. Durna Corum
3
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
4
Orhan Corum
ORCID: 0000-0003-3168-2510
Anahtar Kelimeler
Bioavailability
Broodstock
Carprofen
Pharmacokinetics
Rainbow trout
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
13
Atıf
4
Yazar
5
Anahtar Kelime