Scopus
YÖKSİS Eşleşti
Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep
Journal of Veterinary Pharmacology and Therapeutics · Kasım 2021
YÖKSİS Kayıtları
Effect of ketoprofen and tolfenamic acid on intravenous pharmacokinetics of ceftriaxone in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiKasım 2021
Cilt / Sayfa44 · 945-951
Scopus ID2-s2.0-85111259601
Özet
In this study, the pharmacokinetics of ceftriaxone (40 mg/kg) was determined following a single intravenous (IV) administration of ceftriaxone alone and co-administration with ketoprofen (3 mg/kg) or tolfenamic acid (2 mg/kg) in sheep. Eight healthy Akkaraman sheep (2.4 ± 0.3 years and 44 ± 4 kg of body weight) were used. The study was carried out according to the longitudinal design in three periods with a 15-day washout period between administrations. In the first period, sheep received ceftriaxone alone via an IV injection. In the second and third periods, the same sheep received ceftriaxone in combination with ketoprofen and tolfenamic acid, respectively. Plasma concentrations of ceftriaxone were assayed by high-performance liquid chromatography and analyzed using non-compartmental analysis. Following the administration of ceftriaxone alone, the elimination half-life (t1/2ʎz), area under the plasma concentration–time curve from zero (0) hours to infinity (∞) (AUC0-∞), total clearance (ClT), and volume of distribution at steady state were 1.42 h, 182.41 h*µg/ml, 0.22 L/h/kg, and 0.17 L/kg, respectively. While ketoprofen and tolfenamic acid significantly increased the t1/2ʎz and AUC0-∞ of ceftriaxone, they significantly reduced the ClT. Ceftriaxone (40 mg/kg, IV) in concurrent use with ketoprofen and tolfenamic acid can be administrated at the 12 h dosing intervals to maintain T> minimum inhibitory concentration (MIC) values above 60% in the treatment of infections caused by susceptible pathogens with the MIC value of ≤0.75 and ≤1 μg/mL, respectively, in sheep with an inflammatory condition.
Yazarlar (6)
1
Gul Cetin
2
D. Durna Corum
3
Orhan Corum
ORCID: 0000-0003-3168-2510
4
O. Atik
5
Devran Coskun
ORCID: 0000-0003-1151-1861
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
ceftriaxone
ketoprofen
pharmacokinetics
sheep
tolfenamic acid
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Metrikler
2
Atıf
6
Yazar
5
Anahtar Kelime