Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of enrofloxacin following single oral administration of different doses in brown trout (Salmo trutta)
Animals · Kasım 2021
YÖKSİS Kayıtları
Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)
Animals · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiAnimals
Yayın TarihiKasım 2021
Cilt / Sayfa11
Scopus ID2-s2.0-85117946736
Erişim🔓 Açık Erişim
Özet
The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of en-rofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non‐compart-mental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose‐normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non‐linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96‐fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 μg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout.
Yazarlar (6)
1
Kamil Üney
ORCID: 0000-0002-8674-4873
2
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
3
D. Durna Corum
4
Rahmi Can Ozdemir
5
Soner Bilen
ORCID: 0000-0001-9459-8178
6
Orhan Corum
ORCID: 0000-0003-3168-2510
Anahtar Kelimeler
Brown trout
Enrofloxacin
Pharmacodynamics
Pharmacokinetics
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
16
Atıf
6
Yazar
4
Anahtar Kelime