Scopus
YÖKSİS Eşleşti
Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)
British Poultry Science · Ocak 2022
YÖKSİS Kayıtları
Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)
BRITISH POULTRY SCIENCE · 2022 SCI
PROFESÖR KAMİL ÜNEY →
Pharmacokinetics of intravenous meloxicam, ketoprofen and tolfenamic acid in chukar partridge (Alectoris chukar)
British Poultry Science · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiBritish Poultry Science
Yayın TarihiOcak 2022
Cilt / Sayfa63 · 14-20
Scopus ID2-s2.0-85121293739
Özet
1. The aim of this study was to determine the pharmacokinetics of meloxicam (MLX, 1 mg/kg body weight (BW)), ketoprofen (KETO, 2 mg/kg BW), and tolfenamic acid (TA, 2 mg/kg BW) in chukar partridge (Alectoris chukar) following intravenous (IV) administration. 2. Twenty-four healthy chukar partridges were randomly divided into three equal groups (n = 8) as MLX, KETO and TA. Plasma concentrations of MLX, KETO and TA were measured using high-performance liquid chromatography−ultraviolet detection and analysed using non-compartmental analysis. 3. No adverse effects were determined in chukar partridges after IV administration of MLX, KETO and TA. MLX, KETO and TA were detected in plasma up to 10, 12 and 12 h, respectively. The terminal elimination half-life of MLX, KETO and TA was 1.22, 1.77 and 1.95 h, respectively. MLX, KETO and TA exhibited volumes of distribution at a steady-state of 0.03, 0.23 and 0.41 l/kg BW, respectively. The total plasma clearance of MLX, KETO and TA was 0.02, 0.11 and 0.15 l/h/kg, respectively. The extraction ratios for MLX, KETO and TA were calculated as 0.002, 0.011 and 0.016, respectively. 4. MLX, KETO and TA offer treatment in chukar partridges for various conditions with an absence of adverse reactions and properties such as short elimination half-life and low volume of distribution. However, there is a need to establish the safety and adverse effects of repeated administration, pharmacokinetics of other administration routes and pharmacological efficacy of MLX, KETO and TA in chukar partridges.
Yazarlar (9)
1
Gul Cetin
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
O. Atik
5
Feray Altan
6
Erdinc Turk
ORCID: 0000-0003-1735-1774
7
Ibrahim Ozan Tekeli
ORCID: 0000-0002-6845-2279
8
Hatice Eser Faki
9
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Chukar partridge
HPLC-UV
ketoprofen
meloxicam
tolfenamic acid
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Metrikler
8
Atıf
9
Yazar
5
Anahtar Kelime