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Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations

Food Additives and Contaminants Part A · Ocak 2022

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YÖKSİS Kayıtları
Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT · 2022 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 4 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations
2018 ISSN: 1944-0049 SCI
Prof. Dr. AYŞE ER →
title Plasma and tissue disposition of danofloxacin in brown trout ( iSalmo trutta fario)/i after intravenous and intramuscular administrations/title
2018 ISSN: 1944-0049 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
title Pharmacokinetics, bioavailability and tissue residues of doxycycline in Japanese quails ( iCoturnix coturnix japonica/i ) after oral administration/title
2020 ISSN: 1944-0049 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Plasma and muscle tissue disposition of enrofloxacin in Nile tilapia (Oreochromis niloticus) after intravascular, intraperitoneal, and oral administrations
2022 ISSN: 1944-0049 SCI Q2
Prof. Dr. KAMİL ÜNEY →

Makale Bilgileri

Dergi Food Additives and Contaminants Part A
ISSN19440049
Yayın TarihiOcak 2022
Cilt / Sayfa39 · 1806-1817
DOI10.1080/19440049.2022.2121429
Scopus ID2-s2.0-85139130461
Özet The aim of the study was to investigate the plasma and muscle pharmacokinetic of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) in Nile tilapia (Oreochromis niloticus) following single intravascular (IV), intraperitoneal (IP), or oral (PO) administration at 30 ± 1 °C. In this study, 234 healthy Nile tilapia (120–150 g) were used. The fish received a single IV, IP, or PO treatment of ENR at a dose of 10 mg/kg. The plasma and muscle tissue concentrations of ENR and CIP were measured using high–performance liquid chromatography with fluorescence detection and were evaluated using non–compartmental analysis. The elimination half–life, volume of distribution at steady state, and total body clearance of ENR were 21.7 h, 2.69 L/kg, and 0.09 L/h/kg, respectively. The peak plasma concentrations of ENR after IP or PO administration were 6.11 and 4.21 µg/mL at 0.25 and 2 h, respectively. The bioavailability of ENR for IP or PO routes was 78% and 86%, respectively. AUC(0–120)muscle/AUC(0–120)plasma ratios following the IV, IP, or PO administrations were 1.43, 1.49, and 1.07, respectively. CIP was detected after all routes, but the AUC0–last ratios of CIP to ENR were <1.0% for plasma and muscle. ENR was detected up to 120 h following the IV, IP, or PO administrations. The long residence time of ENR after single IV, IP, or PO administration ensured the plasma concentration was ≥1 × MIC for bacteria with threshold MIC values of 0.92, 0.72, and 0.80 μg/mL over the whole 120 h observed. However, further studies are necessary to determine the optimum pharmacokinetic/pharmacodynamics data of ENR for the treatment of infections caused by susceptible bacteria in tilapia.

Yazarlar (11)

1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
3
D. Durna Corum
4
Yigit Tastan
ORCID: 0000-0002-6782-1597
5
Ruby C. Gonzales
6
Osman Nezih Kenanoglu
ORCID: 0000-0002-5097-6656
7
Dan M. Arriesgado
8
Victor R. Navarro
9
Soner Bilen
ORCID: 0000-0001-9459-8178
10
Adem Yavuz Sonmez
ORCID: 0000-0002-7043-1987
11
Kamil Üney
ORCID: 0000-0002-8674-4873

Anahtar Kelimeler

bioavailability enrofloxacin muscle tissue Pharmacokinetics rainbow trout

Kurumlar

Kastamonu University
Kastamonu Turkey
Mindanao State University at Naawan
Naawan Philippines
Selçuk Üniversitesi
Selçuklu Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Scimago Dergi (ISSN Eşleşmesi)
Food Additives and Contaminants - Part A
Q2
SJR Skoru0,524
H-Index75
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Chemistry (miscellaneous) (Q2)
Food Science (Q2)
Public Health, Environmental and Occupational Health (Q2)
Health, Toxicology and Mutagenesis (Q3)
Medicine (miscellaneous) (Q3)
Toxicology (Q3)
Dergi sayfasına git

Metrikler

21
Atıf
11
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

KÜ
KAMİL ÜNEY
Prof. Dr.

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