Scopus
YÖKSİS Eşleşti
Pharmacokinetics and bioavailability of meloxicam in Pekin ducks following intravenous, intramuscular and oral administration
Veterinary Anaesthesia and Analgesia · Kasım 2023
YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of meloxicam in Pekin ducks following intravenous, intramuscular and oral administration
Veterinary anaesthesia and analgesia · 2023 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiVeterinary Anaesthesia and Analgesia
Yayın TarihiKasım 2023
Cilt / Sayfa50 · 477-484
Scopus ID2-s2.0-85168581122
Özet
Objective: To determine the pharmacokinetics and bioavailability of meloxicam following intravenous (IV), intramuscular (IM), and oral administrations at a dose of 1.0 mg kg–1 in Pekin ducks. Study design: Randomized experimental trial. Animals: A total of 18 clinically healthy male Pekin ducks. Methods: Pekin ducks were randomly assigned to three groups of six ducks: IV, IM and oral. Meloxicam (1.0 mg kg–1) was administered to each Pekin duck. A non-compartmental analysis was used to evaluate pharmacokinetic parameters. Results: No local or systemic adverse effects were observed in any bird. Meloxicam was detected in the plasma up to 120 hours following IV, IM or oral administration. The elimination half-life of the IV route was slightly shorter than that of the IM and oral routes (p < 0.05). Following IV administration, volume of distribution at steady state and total clearance were 133.17 mL kg–1 and 6.68 mL kg–1 hour–1, respectively. The mean absorption time was 2.29 hours for IM and 1.13 hours for oral route. There were significant differences between IM and oral administration for the peak plasma concentration (Cmax), time to reach Cmax and bioavailability (p < 0.05). Conclusions and clinical relevance: Meloxicam showed long elimination half-life and high bioavailability following IM and oral administration. Meloxicam in Pekin ducks provided the effective therapeutic concentration indicated in other species for up to 48 hours. However, there is a need to determine the clinical efficacy of meloxicam in Pekin ducks.
Yazarlar (4)
1
Devran Coskun
ORCID: 0000-0003-1151-1861
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
duck
meloxicam
pharmacokinetics
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Metrikler
2
Atıf
4
Yazar
4
Anahtar Kelime