Scopus
YÖKSİS Eşleşti
Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep
Journal of Veterinary Pharmacology and Therapeutics · Mayıs 2024
YÖKSİS Kayıtları
Pharmacokinetics of meloxicam following intravenous administration at different doses in sheep.
Journal of veterinary pharmacology and therapeutics · 2024 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiMayıs 2024
Cilt / Sayfa47 · 202-207
Scopus ID2-s2.0-85178223399
Özet
The aim of this study is to determine the pharmacokinetic change after intravenous administration of meloxicam at doses of 0.5, 1 and 2 mg/kg to sheep. The study was carried out on six Akkaraman sheep. Meloxicam was administered intravenously to each sheep at 0.5, 1, and 2 mg/kg doses in a longitudinal pharmacokinetic design with a 15-day washout period. Plasma concentrations of meloxicam were determined using the high performance liquid chromatography-ultraviolet, and pharmacokinetic parameters were evaluated by non-compartmental analysis. Meloxicam was detected up to 48 h in the 0.5 mg/kg dose and up to 96 h in the 1 and 2 mg/kg doses. As the dose increased from 0.5 to 2 mg/kg, terminal elimination half-life, and dose normalized area under the concentration versus time curve increased and total clearance decreased. Compared to the 1 mg/kg dose, it was determined that Vdss decreased and C0.083h increased in the 2 mg/kg dose. Meloxicam provided the therapeutic concentration of >0.39 μg/mL reported in other species for 12, 48 and 96 h at 0.5, 1 and 2 mg/kg doses, respectively. These results show that meloxicam exhibits non-linear pharmacokinetics and will achieve unpredictable plasma concentrations when administered IV for a rapid effect at dose of ≥1 mg/kg in sheep.
Yazarlar (8)
1
Huseyin Gungor
ORCID: 0000-0002-2506-3855
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
A. S. Kumru
5
Gökhan Yilmaz
ORCID: 0000-0001-6495-5488
6
Devran Coskun
ORCID: 0000-0003-1151-1861
7
Alparslan Coskun
8
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
increasing dose
meloxicam
pharmacokinetics
sheep
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey