Scopus
🔓 Açık Erişim
SJR Q1
Regulation of adenosine levels during cerebral ischemia
Acta Pharmacologica Sinica · Ocak 2013
Makale Bilgileri
ISSN16714083
Yayın TarihiOcak 2013
Cilt / Sayfa34 · 60-66
Scopus ID2-s2.0-84872065655
Erişim🔓 Açık Erişim
Özet
Adenosine is a neuromodulator with its level increasing up to 100-fold during ischemic events, and attenuates the excitotoxic neuronal injury. Adenosine is produced both intracellularly and extracellularly, and nucleoside transport proteins transfer adenosine across plasma membranes. Adenosine levels and receptor-mediated effects of adenosine are regulated by intracellular ATP consumption, cellular release of ATP, metabolism of extracellular ATP (and other adenine nucleotides), adenosine influx, adenosine efflux and adenosine metabolism. Recent studies have used genetically modified mice to investigate the relative contributions of intra- and extracellular pathways for adenosine formation. The importance of cortical or hippocampal neurons as a source or a sink of adenosine under basal and hypoxic/ischemic conditions was addressed through the use of transgenic mice expressing human equilibrative nucleoside transporter 1 (hENT1) under the control of a promoter for neuron-specific enolase. From these studies, we conclude that ATP consumption within neurons is the primary source of adenosine in neuronal cultures, but not in hippocampal slices or in vivo mice exposed to ischemic conditions. © 2013 CPS and SIMM All rights reserved.
Yazarlar (7)
1
Stephanie Chu
2
Wei Xiong
3
Dali Zhang
4
Hanifi Soylu
5
Chao Sun
6
Benedict C. Albensi
7
Fiona E. Parkinson
Anahtar Kelimeler
adenosine
ATP
cerebral ischemia
hENT1 transgenic mice
hippocampus
nucleoside transport
Kurumlar
Saint Boniface General Hospital Research Centre
Winnipeg Canada
University of Manitoba
Winnipeg Canada
Scimago Dergi (ISSN Eşleşmesi)
Acta Pharmacologica Sinica
Q1
SJR Skoru2,691
H-Index134
YayıncıSpringer Nature
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q1)
Pharmacology (Q1)
Pharmacology (medical) (Q1)
Metrikler
36
Atıf
7
Yazar
6
Anahtar Kelime