Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Doxorubicin-induced oxidative stress injury: The protective effect of kumiss on cardiotoxicity
Journal of the Hellenic Veterinary Medical Society · Ocak 2022
YÖKSİS Kayıtları
Doxorubicin-induced oxidative stress injury: The protective effect of kumiss on cardiotoxicity
Journal of the Hellenic Veterinary Medical Society · 2022 SCI-Expanded
Dr. Öğr. Üyesi HARUN YONAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Relationship Between DGAT1 Gene Polymorphism and Some Growth Traits in Anatolian Merino and Akkaraman Sheep
2025 ISSN: 1792-2720 SCI Q4
Arş. Gör. AYŞE NUR TANIŞ →
Clinical importance of lipid profile in neonatal calves with sepsis
2018 ISSN: 1792-2720 SCI-Expanded
Prof. Dr. HASAN GÜZELBEKTEŞ →
The investigation of xylazine, detomidine, isoflurane and sevoflurane anaesthetic combinations on clinical, laboratory and cardiovascular parameters and on intraocular pressure in horses
2019 ISSN: 1792-2720 SCI-Expanded
Prof. Dr. MUSTAFA ARICAN →
Effect of nebulized formoterol, ipratropium bromide, and furosemide in combination with fluticasone propionate on arterial blood gases of premature calves with respiratory distress syndrome
2020 ISSN: 1792-2720 SSCI
Prof. Dr. BÜNYAMİN TRAŞ →
Effect of nebulized formoterol, ipratropium bromide, and furosemide in combination with fluticasone propionate on arterial blood gases of premature calves with respiratory distress syndrome
2020 ISSN: 1792-2720 SCI-Expanded
Prof. Dr. NURİ BAŞPINAR →
Effects of Dietary Supplementation of Propolis on Performance, Egg Quality and Blood Parameters of
Layer Quails
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. OSMAN OLGUN →
Effect of the addition of bee pollen to the diet on performance, eggshell quality and serum parameters in layer quails
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. OSMAN OLGUN →
Influence of Organic Iron Enriched Diets on Performance, Egg Quality, Blood Haematological and Biochemical Constituents in Quails
2022 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. ALPÖNDER YILDIZ →
Effects of Adding Spirulina platensis to Laying Hen Rations on Performance, Egg Quality, and Some Blood Parameters
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. YUSUF CUFADAR →
The evaluation of dietary application of conjugated linoleic acid on performance, egg quality, blood parameters, antioxidant capacity and egg yolk cholesterol parameters in layer quails
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. YUSUF CUFADAR →
Oxidative Stress and Acute-Phase Response Status During Treatment in Premature Calves with Respiratory Distress Syndrome
2021 ISSN: 1792-2720 scopus
Prof. Dr. MAHMUT OK →
Oxidative Stress and Acute-Phase Response Status During Treatment in Premature Calves with Respiratory Distress Syndrome
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. BÜNYAMİN TRAŞ →
The Effect of Curcumin on the Antioxidant System in Diabetic Rats
2021 ISSN: 1792-2720 SCI-Expanded Q3
Prof. Dr. NURCAN DÖNMEZ →
Isolation and antimicrobial resistance of vancomycin resistant Enterococcus spp. (VRE) and methicillin-resistant S. aureus (MRSA) on beef and chicken meat, and workers hands from slaughterhouses and retail shops in Turkey
2021 ISSN: 1792-2720 SCI-Expanded Q4
Doç. Dr. YUSUF BİÇER →
Isolation and antimicrobial resistance of vancomycin resistant Enterococcus spp. (VRE) and methicillin-resistant S. aureus (MRSA) on beef and chicken meat, and workers hands from slaughterhouses and retail shops in Turkey
2021 ISSN: 1792-2720 SCI-Expanded Q4
Doç. Dr. ARİFE EZGİ TELLİ →
Effect of the addition of bee pollen to the diet on performance, eggshell quality
and serum parameters in layer quails
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. ALPÖNDER YILDIZ →
Effect of hempseed meal on performance, egg quality and egg yolk fatty acids
content in laying quails
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. YUSUF CUFADAR →
The effects of cGnRH on gonadotropin secretion and hatching traits in Japanese quail
2021 ISSN: 1792-2720 SCI-Expanded
Prof. Dr. ALİ AYGÜN →
Clinical and bacteriological analysis of respiratory tract infections in sheltered dogs and determination of antibacterial treatment options
2021 ISSN: 1792-2720 SCI-Expanded Q4
Prof. Dr. MEHMET MADEN →
Isolation and antimicrobial resistance of vancomycin resistant Enterococcus spp. (VRE) and methicillin-resistant S. aureus (MRSA) on beef and chicken meat, and workers hands from slaughterhouses and retail shops in Turkey
2021 ISSN: 1792-2720 SCI-Expanded Q4
Arş. Gör. GAMZE TURKAL →
Makale Bilgileri
ISSN17922720
Yayın TarihiOcak 2022
Cilt / Sayfa73 · 4545-4558
Scopus ID2-s2.0-85141862594
Erişim🔓 Açık Erişim
Özet
Doxorubicin (DOX), which is used in cancer treatment, is an effective chemotherapy agent with many side effects. Cardiotoxicity, on the other hand, is the most important side effect, and it has pushed us to work with kumiss, an alcoholic beverage made from mare’s milk, rich in fermentates, trace elements, antibiotics, vitamins, ethyl alcohol, lactic acid and carbonic acid. The aim of this study was to investigate the effect of kumiss on cardiotoxicity caused by DOX. Twenty-eight Wistar-Albino male rats were divided into 4 groups: There was no intervention in the first group (control). The second group received 2 ml/kg/day of kumiss by gavage needle for 7 days, a single dose of 20 mg/kg, intraperitoneal DOX to the third group, and kumiss+DOX to the fourth group. Kumiss application was started 7 days before DOX administration and continued for 7 days. On the 7th day of kumiss application, DOX was administered intraperitoneally. The malondialdehyde (MDA), reduced glutathione (GSH) levels and antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G6PD) and glutathione-S-transferase (GST) activities were determined in order to determine their effectiveness in the pathogenesis of cardiotoxicity in cardiac and blood tissues. When the DOX group was compared with the control group, an increase in MDA (p<0.001, p<0.001) and GSH (p<0.001, p=0.002) levels and a decrease in CAT (p=0.001, p<0.001), GSH-Px (p<0.001, p<0.001), G6PD (p<0.001, p=0.001) and GST (p=0.003) activities were found, and no statistically significant difference was found in SOD activity. Histopathologically, degeneration, necrosis, hemorrhage and oedema were observed in the DOX administered group. When compared with the group treated with DOX, it was observed that MDA, GSH levels and antioxidant enzyme activities reached the control group values in the group administered kumiss with DOX. In conclusion, it was determined that an increase in lipid peroxidation products and a decrease in antioxidant enzymes may play a role in the pathogenesis of DOX-induced cardiotoxicity, a potent chemotherapeutic drug, and it has been shown that protects against DOX-induced oxidative damage.
Yazarlar (4)
1
Seval Yilmaz
ORCID: 0000-0002-2040-9247
2
Emre Kaya
ORCID: 0000-0002-7445-3091
3
Harun Yonar
4
A. S. Mendil
Anahtar Kelimeler
Antioxidant
Cardiotoxicity
Doxorubicin
Kumiss
Malondialdehyde
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Firat Üniversitesi
Elazig Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of the Hellenic Veterinary Medical Society
Q3
SJR Skoru0,200
H-Index18
YayıncıHellenic Veterinary Medical Society
ÜlkeGreece
Veterinary (miscellaneous) (Q3)
Metrikler
5
Atıf
4
Yazar
5
Anahtar Kelime