Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
Revista Cientifica De La Facultad De Veterinaria · Ocak 2024
YÖKSİS Kayıtları
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
Dr. Öğr. Üyesi HARUN YONAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded Q4
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Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
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Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded Q4
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Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
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Determination of Embryotoxic effects of Atipamezole using in ovo model
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Evaluation of tumor necrosis Factor Alpha, Interferon Gamma, Procalcitonin and Neopterin levels in Brucella seropositive cattle
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ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
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Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
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Determination of the embryotoxic effect of Metronidazole using an in ovo model
2024 ISSN: 0798-2259 SCI-Expanded Q4
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ELISA–based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 CABI
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ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. NERMİN IŞIK USLU →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 SCI-Expanded Q4
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Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ZAFER SAYIN →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
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Morphometric investigation of the effects of Azoxymethane, Diallyl disulfide and corn oil use on humerus and femur development in rats
2024 ISSN: 0798-2259 SCI-Expanded Q4
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Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
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Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ENDER ERDOĞAN →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Pathological and biochemical investigation of the effects of Silybum marianum against Methomyl damage in broiler liver
2024 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN YONAR →
Makale Bilgileri
ISSN07982259
Yayın TarihiOcak 2024
Cilt / Sayfa34
Scopus ID2-s2.0-85192997713
Erişim🔓 Açık Erişim
Özet
This study aimed to investigate the effect of propolis on pyruvate kinase (PK) which is a key enzyme in glycolysis and superoxide dismutase (SOD), an antioxidant enzyme on toxicity induced by DOX in different tissues. Using molecular docking, It was looked into how propolis affected the enzymes responsible for glycolysis and the antioxidant system. There was no application in the first group (control). The second group received 100 mg·kg-1 day of propolis by gavage needle for 7 days, a single dose of 20 mg·kg-1 intraperitoneal DOX to the third group, and propolis+DOX to the fourth group. Two days prior to DOX administration, propolis application began, and it lasted for seven days. PK and SOD activities were determined in liver, heart, kidney, and testis tissues, and molecular docking was applied to ratify the activity of some propolis components (caffeic acid phenethyl ester (CAPE) and Quercetin) on PK and SOD enzymes. When the DOX group was compared with the control group, a decrease in PK and SOD activities were found, and significant difference was found in PK and SOD activities. Administration of DOX decreased PK and SOD activities of liver, heart, kidney, and testis tissues. In conclusion, our study reveals that DOX disrupts glycolysis in rat tissues. CAPE and Quercetin compounds were shown to interact similarly with the cocrystal ligands of PK and SOD. In addition, when the interaction types of these compounds especially on PK and the docking scores obtained were examined, it can be said that they show higher affinity than DOX.
Yazarlar (4)
1
Seval Yilmaz
ORCID: 0000-0002-2040-9247
2
Emre Kaya
ORCID: 0000-0002-7445-3091
3
Harun Yonar
4
Harun Uslu
ORCID: 0000-0001-8827-8557
Anahtar Kelimeler
Doxorubicin
molecular docking
pyruvate kinase
superoxide dismutase
toxicity
Kurumlar
Firat Üniversitesi
Elazig Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Revista Cientifica de la Facultad de Veterinaria
Q4
OA
SJR Skoru0,138
H-Index16
YayıncıUniversidad del Zulia, Facultad de Ciencias Veterinarias
ÜlkeVenezuela
Animal Science and Zoology (Q4)
Food Science (Q4)
Immunology and Microbiology (miscellaneous) (Q4)
Veterinary (miscellaneous) (Q4)