Scopus
YÖKSİS Eşleşti
Zinc Supplementation Improves ZIP14 (SLC39A14) Levels in Cerebral Cortex Suppressed by icv-STZ Injection
Noropsikiyatri Arsivi · Ocak 2024
YÖKSİS Kayıtları
Zinc Supplementation Improves ZIP14 (SLC39A14) Levels in Cerebral Cortex Suppressed by icv-STZ Injection
ARCHIVES OF NEUROPSYCHIATRY · 2024 SCI-Expanded
PROFESÖR HALUK GÜMÜŞ →
Zinc Supplementation Improves ZIP14 (SLC39A14) Levels in Cerebral Cortex Suppressed by icv-STZ Injection
The Archives of Neuropsychiatry · 2023 SCI-Expanded
PROFESÖR HALUK GÜMÜŞ →
The Effect of Chronic Swimming Exercise and Vitamin E Supplementation on
Bone Element Metabolism in Epileptic Rats
Nöropsikiyatri Arşivi · 2024 Art Index (Art Research Database, EBSCO)
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiNoropsikiyatri Arsivi
Yayın TarihiOcak 2024
Cilt / Sayfa61 · 11-14
Scopus ID2-s2.0-85187136596
Özet
Introduction: Metabolic dysfunctions are critical in the pathology of Alzheimer’s disease. Impaired zinc homeostasis, in particular, is a significant issue in this disease that has yet to be explained. Gene expression of ZIP14 in brain tissue has been previously reported. But to date, only one study has reported reduced ZIP14 levels in aged brain tissue. We investigated how dietary zinc deprivation and supplementation impact ZIP14 levels in the cerebral cortex in rats with sporadic Alzheimer’s disease (sAH) produced by intracerebroventricular streptozotocin (icv-STZ). Impaired zinc homeostasis, in particular, is a significant issue with this condition that has yet to be elucidated. Methods: Animals were divided into 5 groups in equal numbers (n=8): Sham 1 group: icv received artificial cerebrospinal fluid (aCSF); Sham 2 group: retrieved icv aCSF and intraperitoneal (ip) saline, STZ group: received 3 mg/kg icv-STZ; STZ-Zn-Deficient group: received 3 mg/ kg icv-STZ and fed a zinc-deprived diet; STZ-Zn-Supplemented: It received 3 mg/kg icv-STZ and ip zinc sulfate (5 mg/kg/day ZIP 14 levels (ng/L) in cortex tissue samples taken from animals sacrificed under general anesthesia were determined by ELISA at the final stage of the experimental applications. Results: Decreased ZIP14 levels in the sporadic Alzheimer’s group were severely by zinc deficiency. Zinc supplementation treated the reduction in ZIP14 levels. Conclusion: The results of the current study show that ZIP14 levels in cerebral cortex tissue, which are suppressed in the experimental rat Alzheimer model and are even more critically reduced in zinc deficiency, can be restored by zinc supplementation.
Yazarlar (5)
1
Saltuk Bugra Baltaci
2
Haluk Gümüş
3
Omer Unal
4
Gozde Acar
5
Aysenur Feyza Bayiroglu
Anahtar Kelimeler
Cerebral cortex
icv-STZ Injection
zinc deficiency
zinc supplementation
ZIP14
Kurumlar
İstanbul Medipol Üniversitesi
Istanbul Turkey
Kirikkale Üniversitesi
Kirikkale Turkey
Selçuk Üniversitesi
Selçuklu Turkey