Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine
Journal of Research in Pharmacy · Ocak 2019
YÖKSİS Kayıtları
Degradation studies and thermodynamic parameters in aqueous solution of chemotherapeutic agents: Daunorubicin, doxorubicin and vincristine
Journal of research in pharmacy (online) · 2019 TR DİZİN
Dr. Öğr. Üyesi TUĞÇE GÖVER →
Makale Bilgileri
Dergi
Journal of Research in Pharmacy
Yayın TarihiOcak 2019
Cilt / Sayfa23 · 822-831
Scopus ID2-s2.0-85072920795
Erişim🔓 Açık Erişim
Özet
The degradation of daunorubicin (DNR), doxorubicin (DXR) and vincristine (VCR) as chemotherapeutic agents was investigated under stress conditions such as acidic and alkaline media, oxidation, photolytic and heating. The degradation pathway determined by high-performance liquid chromatography (HPLC). Daunorubicin, doxorubicin and vincristine completely disintegrated in the basic medium. It has been determined that these drugs are resistant to heat. Daunorubicin and doxorubicin are resistant to UV light. However, vincristine is not very stable such as the other two compounds against UV light. The kinetic and thermodynamic parameters of daunorubicin, doxorubicin and vincristine were investigated in neutral media with different temperatures by electrochemical technique. Enthalpy, entropy and Gibbs free energy parameters were investigated in pH 7.4 phosphate buffer (PB) solution due to stability of these drugs at this pH. The studied chemotherapeutic agents showed endothermic process on glassy carbon-based electrode surface. Daunorubicin, doxorubicin and vincristine showed strongly adsorption process in room temperature. However, it showed diffusion property from electrode to solution with increasing the temperature values.
Yazarlar (5)
1
Nurgül Karadaş Bakirhan
2
Bediha Akmeşe
3
Tuğçe Göver
4
Hamideh Imanzadeh
5
Sibel A. Özkan
Anahtar Kelimeler
Chemotherapeutic agent
Degradation
Drug stability
Liquid chromatography
Temperature effect
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Azarbaijan Shahid Madani University
Tabriz Iran
Hitit University
Corum Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
4
Atıf
5
Yazar
5
Anahtar Kelime