Scopus
Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients
Journal of B.U.ON. · Ekim 2012
Makale Bilgileri
DergiJournal of B.U.ON.
Yayın TarihiEkim 2012
Cilt / Sayfa17 · 663-668
Scopus ID2-s2.0-84872379495
Özet
Purpose: Hypoxia is common in many solid tumors such as breast, head-neck, and soft tissue malignancies. Hypoxia causes overexpression of hypoxia inducible factor-1 alpha (HIF-1α) and carbonic anhydrase IX (CA IX) which are associated with unfavorable prognosis in breast cancer. In our study, we evaluated HIF-1α and CA IX expression in patients with breast cancer. Methods: Between June 1996 and June 2008, 111 women with breast cancer were evaluated. Estrogen receptor (ER) and progesterone receptor (PR) status and Her2/ neu expression were evaluated by immunohistochemical methods. Her-2/neu expression was also assessed by FISH method when needed. Two groups were created: ER and PR positive, Her-2/neu negative (group 1, n=56); and ER and PR negative, Her-2/neupositive (group 2, n=55). HIF-1α and CA IX expressions were investigated in both groups and results were compared. In addition, we investigated the association between HIF-1α and CA IX expressions with stage, grade, lymph node metastasis, tumor size, menopause status and survival. Results: Median patient age in group 1 was 52 years (range 34-77), and in group 2 47years (range 27-83). HIF1α expression was detected in 26 (46.4%) of group 1 and in 46 (83.6%) of group 2 patients (p=0.0001). CA IX expression was detected in 25 (46.4%) of group 1 and in 37(67.3%) of group 2 patients (p=0.013). In group 1, median disease free survival (DFS) was 97 months and in group 2 46 months (p=0.0308). In group 1, median overall survival (OS) was 108 months and in group 2 75 months (p=0.0339). Conclusion: HIF-1a and CA IX overexpressions are observed more often in ER and PR negative, Her-2/neu positive breast cancer and are associated with poor survival. © 2012 Zerbinis Medical Publications.
Yazarlar (10)
1
Ali Osman Kaya
2
N. Gunel
3
Mustafa Benekli
4
Nalan Akyürek
5
Süleyman Büyükberber
6
H. Tatli
7
Ugur Coskun
8
Ramazan Yildiz
9
Emel Yaman
10
Banu Turgut Ozturk
ORCID: 0000-0003-0702-6951
Anahtar Kelimeler
Breast cancer
CA IX
HIF-1α
Prognosis
Tumor hypoxia
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Metrikler
37
Atıf
10
Yazar
5
Anahtar Kelime